Author (year) | Country (Reference number) | Study design (Sex) | Participants numbers | Type and dose of Propolis administered | Study Duration (Mean age of subjects) | Outcome measures |
---|---|---|---|---|---|---|
Zakerkish M et al. (2019) [81] | Iran | Parallel RCT (M/F) | 94 type 2 diabetes patients | 2 capsules daily each capsule contain: 500 mg | 3-month (55.1 years) | S.R in HOMA-IR, Insulin, HbA1C, and 2 h-PPS levels in Propolis group compared with Placebo N.S in FPG between two groups |
Afsharpour F et al. (2019) [35] | Iran | Parallel RCT (M/F) | 62 type 2 diabetes patients | 3 capsules daily each capsule contain: 500 mg | 8-week (50.4 years) | S.R in FPG, HOMA-IR, Insulin, HbA1C, and 2 h-PPS levels in Propolis group compared with Placebo |
Gao W et al. (2018) [18] | China | Open-label CT study (M/F) | 61 type 2 diabetes patients | 1 capsule once daily each capsule: 900 mg | 18-week (59.1 years) | N.S in FPG, Insulin and HbA1C levels in Propolis group compared with Placebo |
Samadi N et al. (2017) [105] | Iran | Parallel RCT (M/F) | 66 type 2 diabetes patients | 3 pills daily each pill contain: 300 mg | 12-week (53.6 years) | S.R in FPG S.R in HbA1C level |
El-Sharkawy H et al. (2016) [14] | Egypt | Parallel RCT (M/F) | 50 type 2 diabetes patients | 1 capsule once daily each capsule: 400 mg | 6-month (50.1 years) | S.R in FPG S.R in HbA1C level |
Zhao L et al. (2016) [82] | China | Parallel RCT (M/F) | 65 type 2 diabetes patients | 1 capsule once daily each capsule: 900 mg | 18-week (60.1 years) | N.S in Serum glocuse, Insulin and HbA1C levels in Propolis group compared with Placebo |
Fukuda T et al. (2015) [106] | Japan | Parallel RCT (M/F) | 80 type 2 diabetes patients | 1 Tablet daily each tablet contain: 226 mg | 8-week (63.3 years) | N.S in HOMA-IR, Insulin and HbA1C levels in Propolis group compared with Placebo |
Murata K et al. (2004) [117] | Japan | Case series study (M/F) | 12 diabetic adult patients | Propolis Mixed with Mulberry Leaf Extract | 30 days (44–74 years) | S.R in FPG S.R in HbA1C level |