Fig. 1

Impairment of glucose tolerance in T2DM rats. The glucose tolerance of control and type 2 diabetes mellitus (T2DM) rats was evaluated by oral glucose tolerance test (OGTT), and the area under concentration-time curve (AUC) of blood glucose concentration was calculated by the proximity ladder shaped formula: AUC (mmol/L*min) = 1/2 × (BG 0 min + BG 30 min) × 30 min + 1/2 × (BG 30 min + BG 60 min) × 30 min + 1/2 × (BG 60 min + BG 90 min) × 30 min + 1/2 × (BG 90 min + BG 120 min) × 30 min. A is the plasma glucose levels, and B is the AUC. Data are expressed as mean ± S.E.M., n = 5. **P < 0.01 vs Control