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Table 4 Cardiac dysfunction measured by echocardiography in T2DM rats

From: Endogenous asymmetric dimethylarginine accumulation contributes to the suppression of myocardial mitochondrial biogenesis in type 2 diabetic rats

Parameters

Control

Diabetes

HMI (mg/g)

2.26 ± 0.09

2.84 ± 0.13**

HR (bpm)

379.31 ± 2.34

341.13 ± 22.43

CO (ml/min)

46.44 ± 3.29

43.74 ± 3.01

EF (%)

84.80 ± 2.58

54.05 ± 2.87**

FS (%)

55.19 ± 3.75

35.13 ± 0.76**

IVRT (ms)

22.67 ± 0.87

35.30 ± 1.37**

E/A (ratio)

1.66 ± 0.04

0.72 ± 0.04**

ESV (μl)

20.41 ± 4.16

105.86 ± 9.72**

EDV (μl)

140.34 ± 9.41

228.80 ± 9.54**

LVIDs (mm)

2.30 ± 0.18

4.37 ± 0.11**

LVIDd (mm)

5.16 ± 0.19

6.72 ± 0.16**

LVPWs (mm)

3.17 ± 0.13

3.38 ± 0.14

LVPWd (mm)

2.30 ± 0.13

2.32 ± 0.08

IVSs (mm)

2.99 ± 0.11

3.25 ± 0.07

IVSd (mm)

2.05 ± 0.06

2.22 ± 0.07

  1. Data are expressed as mean ± S.E.M., n = 5, **P < 0.01 vs Control
  2. T2DM Type 2 diabetes mellitus, HMI Heart mass index, HR Heart rate, CO Cardiac output, EF Ejection fraction, FS Fractional shortening, IVRT Isovolumic relaxation time, E/A The ratio of early (E) to late (A) left ventricular filling velocities, ESV or EDV End-systolic or end-diastolic volume, LVIDs or LVIDd Left ventricle internal diameter at end-systole or end-diastole, LVPWs or LVPWd Left ventricle posterior wall thickness at end-systole or end-diastole, IVSs or IVSd Interventricular septum thickness at end-systole or end-diastole
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Nutrition & Metabolism

ISSN: 1743-7075

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