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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Fig. 2

Visualization of differentially expressed proteins (DEP) and enrichment analysis. a Function annotations Venn graph of all the identified 697 proteins. b Volcano plot of DEPs. Gray in the Volcano plot indicates the proteins with insignificant differences, red indicates up-regulated and blue indicates down-regulated. We use triangles and squares to highlight the lipid metabolism and transport-related DEPs and metalloproteins, respectively. c Heatmap of DEPs. Each row is corrected for the Z value. Longitudinal is the clustering of samples and horizontal is the clustering of proteins. The heatmap with annotations are provided in the Additional file 4. d Histogram of GO enrichment analyses results. The entries in the histogram are arranged from left to right according to the degree of enrichment, and the curves show the change of enrichment degree. e Protein-protein interaction network of DEPs. Each node represents a protein. The up-regulated protein is in red and down-regulated protein is blue. The size of each node is proportional to the -log10 P-value. The edges represent protein-protein interactions. The width of the edge is proportional to the combined-score in STRING. The module circled by the red line is associated with lipid metabolism and transport

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