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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats

Fig. 2

Impact of cafeteria diet and treadmill exercise intervention on fecal microbiota and inferred microbiome function at 7 weeks. a Shannon’s diversity, b microbial species richness and c evenness. Data expressed as mean ± SEM; n = 11–12; data were analyzed by two-way ANOVA followed by Tukey-adjusted post-hoc testing. d Non-metric multidimensional scaling (Bray-Curtis, 1000 permutations) showing similarity between fecal microbiota samples at 7 weeks. e Muribaculum_OTU72 identified by DESeq2 (adjusted p < 0.05) as differentially abundant with exercise in chow-fed rats. f Relative abundance of OTU72 at 7 weeks. Data expressed as box-and-whisker plots (min, IQR, max); n = 11–12; data were analyzed using Kruskal-Wallis test followed by non-parametric Dunn-Bonferroni post-hoc testing. g Amino acid metabolism, h overall energy metabolism, i D-glutamine and D-glutamate metabolism and j one carbon pool by folate predicted using PICRUSt from fecal microbiome data at 7 weeks. Data are expressed as box-and-whisker plots (min, IQR, max); n = 11–12; were analyzed by Kruskal-Wallis tests (FDR-adjusted overall p-value to account for multiple relevant pathways included in analysis) followed by non-parametric Bonferroni-Dunn post-hoc comparisons. Post-hoc symbols: ap < 0.05 relative to CSed, bp < 0.05 relative to CEx, cp < 0.05 relative to CafSed

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