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Table 1 Anthropometric measures at tissue collection and plasma measures

From: Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats

Measure CSed CEx CafSed CafEx Main Effects (p-value)
Diet Exercise Interaction
Terminal Body Weight (g) 475.4 ± 14.9 455.6 ± 31.4 625.5 ± 26.2a,b 583.3 ± 12.4a,b < 0.001 0.073 0.512
Nasoanal Length (cm) 24.5 ± 0.2 24.4 ± 0.2 25.0 ± 0.2 25.0 ± 0.1b < 0.001 0.914 0.450
Girth (cm) 19.1 ± 0.2 18.9 ± 0.2 22.3 ± 0.6a,b 21.5 ± 0.4a,b < 0.001 0.186 0.505
Liver score 0.17 ± 0.09 0.17 ± 0.09 1.96 ± 0.17a,b 2.08 ± 0.22a,b    < 0.001
Heart Weight (g) 1.39 ± 0.04 1.34 ± 0.03 1.69 ± 0.07a,b 1.62 ± 0.03a,b < 0.001 0.170 0.884
Absolute fat mass (g; EchoMRI) 47.51 ± 3.63 38.78 ± 3.09 139.23 ± 16.27a,b 107.35 ± 6.81a,b < 0.001 0.031 0.212
RP Fat Pad Weight (% BW) 2.22 ± 0.16 1.87 ± 0.15 5.87 ± 0.43a,b 4.73 ± 0.47a,b < 0.001 0.022 0.142
Epidydimal Fat Pad Weight (% BW) 2.35 ± 0.14 2.12 ± 0.17 6.01 ± 0.54a,b 4.91 ± 0.21a,b < 0.001 0.032 0.126
Blood Glucose (mmol/L) 9.0 ± 0.4 9.7 ± 0.9 10.4 ± 0.5 10.2 ± 0.5 0.548 0.225 0.111
Plasma Insulin (ng/mL) 0.53 ± 0.12 0.27 ± 0.07 2.09 ± 0.32a,b 1.68 ± 0.43a,b < 0.001 0.246 0.797
Plasma Leptin (ng/mL) 4.72 ± 0.55 3.81 ± 0.34 18.64 ± 1.43a,b 15.21 ± 1.21a,b < 0.001 0.037 0.220
Plasma Triglycerides (mmol/L) 1.16 ± 0.12 0.86 ± 0.08 3.52 ± 0.32a,b 3.27 ± 0.25a,b < 0.001 0.056 0.226
Liver Triglycerides (mg/g tissue) 3.77 ± 0.49 3.65 ± 0.44 23.32 ± 2.52a,b 20.58 ± 2.41a,b < 0.001 0.423 0.465
  1. Blood and plasma measures performed unfasted. Data expressed as mean ± SEM; n = 10–12. Data were analyzed using two-way ANOVA, followed by post-hoc multiple comparisons with a Tukey HSD correction. Liver score was analysed using a Kruskal-Wallis test followed by non-parametric Bonferroni-Dunn post-hoc testing
  2. ap < 0.05 relative to CSed, bp < 0.05 relative to CEx