Table 2 Comparison of demographical, anthropometric, and biochemical data across metabotypes
From: Optimisation of a metabotype approach to deliver targeted dietary advice
|  | Metabotype 1 (n = 71) | Metabotype 2 (n = 97) | Metabotype 3 (n = 39) | p value* | p value** |
|---|---|---|---|---|---|
Demographics and anthropometrics | Â | Â | Â | Â | Â |
 Sex (M/F) | 16/55 | 57/40 | 26/13 | 6.8 × 10–7 | – |
 Age (years) | 29.8 (24.0, 41.4)2 | 26.9 (22.5, 33.7)1,3 | 33.6 (28.1, 44.3)2 | 1.6 × 10–4 | – |
 BMI (kg/m2) | 23.6 (21.9, 25.9)3 | 23.9 (22.2, 26.1)3 | 27.4 (26.0, 32.0)1,2 | 2.0 × 10–6 | – |
 Waist circumference (cm) | 79 (71, 84)3 | 80 (76, 87)3 | 93 (85, 108)1,2 | 2.9 × 10–8 | 1.4 × 10–7 |
 Waist-hip ratio | 0.79 (0.76, 0.84)3 | 0.83 (0.79, 0.87)3 | 0.89 (0.84, 0.94)1,2 | 3.0 × 10–6 | 2.0 × 10–6 |
 Fat mass (%) | 28.0 (22.3, 32.7)3 | 20.0 (13.9, 29.9)3 | 31.4 (22.2, 37.8)1,2 | 8.5 × 10–7 | 4.6 × 10–8 |
 Fat free mass (%) | 72.0 (67.3, 77.7)3 | 80.0 (70.1, 86.1)3 | 68.6 (62.2, 77.8)1,2 | 8.5 × 10–7 | 5.8 × 10–9 |
 SBP (mmHg) | 120 (113, 129) | 123 (115, 129) | 126 (118, 133) | 0.108 | 0.039 |
 DBP (mmHg) | 73 (68, 78)3 | 70 (64, 78)3 | 78 (71, 84)1,2 | 2.3 × 10–4 | 0.010 |
Biochemical markers | Â | Â | Â | Â | Â |
 C-peptide (ng/mL) | 1.60 (0.94, 2.42)3 | 1.81 (1.04, 2.92)3 | 2.82 (1.69, 5.93)1,2 | 9.0 × 10–6 | 1.1 × 10–4 |
 Glucose 120 min (mmol/L) | 4.75 (4.28, 5.21)3 | 4.70 (4.17, 5.28)3 | 5.47 (4.52, 7.00)1,2 | 0.018 | 7.7 × 10–3 |
 GlucoseAUC (mmol/L) | 685 (628, 753)3 | 688 (633, 780)2 | 804 (693, 1032)1,2 | 6.7 × 10–4 | 8.6 × 10–3 |
 Insulin (mU/mL) | 5.69 (3.65, 7.33)3 | 5.15 (3.42, 7.69)3 | 7.99 (5.45, 15.94)1,2 | 7.1 × 10–6 | 6.0 × 10–6 |
 InsulinAUC (mU/mL) | 3208 (2530, 4685)3 | 3224 (2127, 4609)3 | 5746 (4000, 7337)1,2 | 1.0 × 10–6 | 8.8 × 10–7 |
 Glucagon (pg/mL) | 102 (67, 125) | 93 (65, 123) | 105 (74, 135) | 0.473 | 0.069 |
 HOMA-IR | 1.20 (0.82, 1.67)3 | 1.18 (0.77, 1.66)3 | 1.92 (1.25, 3.95)1,2 | 9.7 × 10–8 | 9.9 × 10–7 |
 QUICKI | 0.37 (0.35, 0.40)3 | 0.37 (0.34, 0.40)3 | 0.35 (0.32, 0.37)1,2 | 5.7 × 10–7 | 8.0 × 10–6 |
 Amylin (pM) | 1.59 (0.70, 3.84)3 | 2.34 (1.54, 5.63) | 3.66 (2.13, 6.58)1 | 8.4 × 10–3 | 0.044 |
 NEFA (mmol/L) | 0.54 (0.37, 0.81) | 0.46 (0.31, 0.68) | 0.50 (0.36, 0.72) | 0.519 | 0.085 |
 Leptin (ng/mL) | 1.01 (0.73, 1.54) | 0.89 (0.70, 1.38)3 | 1.17 (0.79, 3.67)2 | 0.025 | 3.5 × 10–3 |
 LSR (ng/mL) | 33.9 (27.8, 42.7) | 28.7 (22.7, 38.2) | 30.5 (23.2, 37.6) | 0.095 | 0.488 |
 Adiponectin (mg/mL) | 5.79 (4.04, 7.93)3 | 4.61 (3.24, 5.86)3 | 3.49 (1.99, 5.01)1,2 | 1.7 × 10–4 | 5.0 × 10–5 |
 Resistin (ng/mL) | 4.28 (3.15, 5.36) | 4.19 (3.35, 5.46) | 4.10 (2.91, 5.70) | 0.792 | 0.456 |
 Visfatin (ng/mL) | 0.91 (0.73, 1.36) | 0.95 (0.73, 1.27) | 1.08 (0.84, 1.37) | 0.578 | 0.906 |
 LDL cholesterol (mmol/L) | 2.55 (2.05, 3.12)2,3 | 2.09 (1.74, 2.48)1,3 | 3.47 (2.72, 3.99)1,2 | 3.9 × 10–12 | 5.0 × 10–6 |
 Apo A1 (mg/dL) | 152 (130, 172)2,3 | 122 (112, 133)1 | 114 (100, 133)1 | 1.7 × 10–12 | 2.9 × 10–7 |
 Apo B (mg/dL) | 77 (64, 90)2,3 | 68 (59, 76)1,3 | 97 (81, 112)1,2 | 1.5 × 10–16 | 2.8 × 10–12 |
 Apo C2 (mg/dL) | 3.69 (2.31, 4.84)2,3 | 3.06 (2.17, 3.81)1,3 | 5.58 (3.90, 7.25)1,2 | 2.4 × 10–4 | 9.6 × 10–5 |
 Apo C3 (mg/dL) | 7.74 (6.01, 8.80)2 | 6.00 (5.12, 7.33)1,3 | 9.27 (7.51, 10.73)2 | 2.0 × 10–5 | 1.2 × 10–3 |
 Apo E (mg/dL) | 2.35 (1.84, 2.79) | 1.95 (1.62, 2.45) | 2.45 (1.89, 2.97) | 0.053 | 0.115 |
 SAA (mg/mL) | 13.7 (10.4, 20.6) | 12.6 (9.0, 19.9) | 15.9 (10.9, 20.4) | 0.307 | 0.472 |
 GGT (U/L) | 15 (11, 24)3 | 15 (12, 21)3 | 22 (17, 36)1,2 | 4.0 × 10–5 | 3.7 × 10–3 |
 ALT (U/L) | 18 (15, 23)3 | 18 (15, 25)3 | 23 (20, 30)1,2 | 2.5 × 10–3 | 0.028 |
 AST (U/L) | 22 (20, 26)3 | 23 (18, 27)3 | 24 (22, 30)1,2 | 0.377 | 0.022 |