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Table 1 Basic characteristics of the overall population by the severity of OSA

From: Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea

Variable Non-OSA (n = 596) Moderate OSA (n = 831) Severe OSA (n = 2580) P value
Demographics
Age (years) 34 (29–43) 43 (35–53) 41 (34–51) < 0.001
Male (%) 596 (100%) 675 (81.2%) 2332 (90.4%) < 0.001
BMI (kg/m2) 24.2 (22.3–26.0) 26.0 (24.07–28.0) 27.7 (25.8–30.1) < 0.001
NC (cm) 38 (36–40) 39 (37–41) 41 (39–43) < 0.001
WC (cm) 89 (83–94) 94 (89–99) 99 (94–105) < 0.001
HC (cm) 98 (94–101) 100 (96–104) 103 (99–108) < 0.001
WHR 0.91 (0.87–0.95) 0.94 (0.91–0.98) 0.96 (0.93–1.0) < 0.001
Biochemistry assays
Glucose (mmol/L) 5.07 (4.71–5.36) 5.23 (4.9–5.69) 5.39 (5.05–5.95) < 0.001
Insulin (uU/mL) 7.56 (5.2–11.34) 10.24 (7.04–14.48) 12.88 (8.92–18.96) < 0.001
HOMA-IR 1.72 (1.11–2.55) 2.41 (1.56–3.48) 3.15 (2.08–4.84) < 0.001
SBP (mmHg) 120 (112–128) 124 (115–134) 127 (120–138) < 0.001
DBP (mmHg) 78 (71–82) 80 (71–87) 81 (76–90) < 0.001
TC (mmol/L) 4.37 (3.84–4.96) 4.73 (4.17–5.40) 4.84 (4.28–5.44) < 0.001
TG (mmol/L) 1.24 (0.84–1.84) 1.61 (1.14–2.29) 1.77 (1.26–2.61) < 0.001
HDL-C (mmol/L) 1.03 (0.92–1.12) 1.02 (0.9–1.12) 1 (0.88–1.14) < 0.001
LDL-C (mmol/L) 2.68 (2.25–3.18) 3 (2.51–3.51) 3.04 (2.53–3.55) < 0.001
ApoA-I (g/L) 1.02 (0.92–1.15) 1.03 (0.92–1.17) 1.04 (0.93–1.16) 0.379
ApoB (g/L) 0.77 (0.65–0.89) 0.84 (0.73–0.98) 0.88 (0.76–1.0) < 0.001
ApoB/ApoA-I 0.74 (0.61–0.89) 0.81 (0.67–0.97) 0.84 (0.71–0.98) < 0.001
Sleep apnea
AHI 2 (0.8–3.4) 21.8 (18.3–25.7) 58.2 (45.1–70.5) < 0.001
Minimum SaO2 92 (89–95) 83 (77–87) 71 (62–79) < 0.001
ODI 2.1 (0.9–3.8) 22.2 (17.3–28.0) 57.9 (44–72.2) < 0.001
MAI 14.4 (10.3–22.5) 22.2 (14.2–31.6) 36.7 (21.6–56.4) < 0.001
Medical history
ESS 7 (3–10) 7 (4–11) 11 (7–15) < 0.001
Non-smoker, N (%) 372 (62.4%) 488 (58.7%) 1300 (50.4%) < 0.001
Non-drinker, N (%) 284 (47.7%) 405 (48.7%) 1131 (43.8%) 0.024
IR (%) 160 (26.8%) 389 (46.8%) 1636 (63.4%) < 0.001
Met S (%) 162 (27.2%) 417 (50.2%) 1660 (64.3%) < 0.001
  1. The data are presented as means and standard deviation; skewed data are presented as the median (IQR), and categorical data as the number (percentage)
  2. GRS genetic risk score, BMI body mass index, NC neck circumference, WC waist circumference, HC hip circumference, WHR waist/hip ratio, HOMA-IR homeostasis model assessment for insulin resistance, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein; cholesterol; ApoA-I apolipoprotein A-I, ApoB apolipoprotein B, ESS Epworth Sleepiness Scale, AHI apnoea–hypopnea index, SaO2 oxygen saturation, ODI oxygen desaturation index, MAI micro-arousal index