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Table 3 Association of risk of APOA-I, APOB level and their GRS with risks of insulin resistance and MetS

From: Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea

  Non-HOMA-IR vs HOMA-IR Non-MetS vs MetS Non-OSA vs moderate to severe OSA
  OR 95%CI P OR 95%CI P OR 95%CI P
APOA-I GRS 0.923 0.880–0.968 < 0.001 0.886 0.845–0.929 < 0.001 0.983 0.920–1.049 0.600
APOA-I GRS* 0.917 0.869–0.967 0.001 0.870 0.827–0.916 < 0.001 0.994 0.924–1.070 0.874
APOB GRS 1.011 0.950–1.076 0.734 1.060 0.997–1.128 0.063 1.011 0.927–1.101 0.811
APOB GRS* 1.364 1.330–1.339 0.610 1.072 1.003–1.147 0.042 1.000 0.907–1.104 0.993
APOB/APOA-I 4.551 3.379–6.129 < 0.001 19.021 13.629–26.545 < 0.001 7.610 4.886–11.852 < 0.001
APOB/APOA-I * 2.285 1.657–3.150 < 0.001 14.488 10.093–20.797 < 0.001 3.237 1.993–5.258 < 0.001
APOA-I 0.573 0.414–0.792 < 0.001 0.131 0.093–0.184 < 0.001 1.307 0.828–2.063 0.250
APOA-I * 0.823 0.566–1.196 0.308 0.09 0.061–0.132 < 0.001 1.336 0.788–2.267 0.282
APOB 6.677 4.654–9.578 < 0.001 12.095 8.349–17.522 < 0.001 31.683 18.231–55.059 < 0.001
APOB* 3.168 2.139–4.691 < 0.001 6.098 4.109–9.051 < 0.001 8.582 4.653–45.830 < 0.001
  1. HOMA-IR homeostasis model assessment of insulin resistance, GRS genetic risk score, Met S metabolic syndrome, APOA-I Apolipoprotein A-I, APOB Apolipoprotein B
  2. *Adjust for age, gender, BMI