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Table 4 Risk of OSA, insulin resistance and MetS according to quintile of APOA-I GRS and APOB GRS

From: Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea

  Top vs bottom quintile unadjusted analysis Top vs bottom quintile adjusted analysis*
OR 95%CI P OR* 95% CI* P*
APOA-I GRS
Non-OSA vs moderate to severe OSA 0.812 0.635–1.039 0.098 0.855 0.654–1.118 0.252
Non-insulin resistance vs insulin resistance 0.753 0.630–0.899 0.002 0.761 0.623–0.929 0.007
Non-MetS vs MetS 0.651 0.546–0.777 < 0.001 0.637 0.526–0.773 < 0.001
APOB GRS
Non-OSA vs moderate to severe OSA 0.997 0.768–1.295 0.984 0.98 0.738–1.301 0.889
Non-insulin resistance vs insulin resistance 1.019 0.848–1.225 0.839 1.032 0.841–1.267 0.761
Non-MetS vs MetS 1.154 0.962–1.384 0.123 1.182 0.971–1.439 0.096
  1. OSA obstructive sleep apnea, HOMA-IR homeostasis model assessment of insulin resistance, GRS genetic risk score, MetS metabolic syndrome, AHI apnoea–hypopnea index, APOA-I Apolipoprotein A-I, APOB Apolipoprotein B
  2. *Adjust for age, gender, BMI