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Table 4 Risk of OSA, insulin resistance and MetS according to quintile of APOA-I GRS and APOB GRS

From: Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea

 

Top vs bottom quintile unadjusted analysis

Top vs bottom quintile adjusted analysis*

OR

95%CI

P

OR*

95% CI*

P*

APOA-I GRS

Non-OSA vs moderate to severe OSA

0.812

0.635–1.039

0.098

0.855

0.654–1.118

0.252

Non-insulin resistance vs insulin resistance

0.753

0.630–0.899

0.002

0.761

0.623–0.929

0.007

Non-MetS vs MetS

0.651

0.546–0.777

< 0.001

0.637

0.526–0.773

< 0.001

APOB GRS

Non-OSA vs moderate to severe OSA

0.997

0.768–1.295

0.984

0.98

0.738–1.301

0.889

Non-insulin resistance vs insulin resistance

1.019

0.848–1.225

0.839

1.032

0.841–1.267

0.761

Non-MetS vs MetS

1.154

0.962–1.384

0.123

1.182

0.971–1.439

0.096

  1. OSA obstructive sleep apnea, HOMA-IR homeostasis model assessment of insulin resistance, GRS genetic risk score, MetS metabolic syndrome, AHI apnoea–hypopnea index, APOA-I Apolipoprotein A-I, APOB Apolipoprotein B
  2. *Adjust for age, gender, BMI