High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats’ brain: the toxic role of high-fat diet

Table 2 Body weight, blood glucose and serum triglyceride level in experimental groups. Rats treated with high-fat, high-protein, low-calorie, low-calorie high-protein diets for 10 weeks. Control adult and old rats treated with rodent standard pellet. After behavioral tests, rats were euthanized and blood were collected (n = 6)

Groups	Body weight (g)		Blood glucose (mg dl)		Serum triglyceride (mg dl)
Groups	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Adult-C	302 ± 22	343 ± 31	85 ± 2	87 ± 3	81 ± 3	84 ± 2
Old-C	367 ± 11^$	396 ± 22	98 ± 4^$	105 ± 4	95 ± 2^$	96 ± 2
High-fat	350 ± 15	379 ± 25	95 ± 4	110 ± 5	93 ± 5	119 ± 5
High-protein	333 ± 27	405 ± 19**	94 ± 2	99 ± 5	96 ± 2	79 ± 3**
Low-calorie	359 ± 16	315 ± 18*	98 ± 3	90 ± 6*	94 ± 6	70 ± 3**
Low-calorie high-protein	337 ± 21	307 ± 16*	99 ± 3	90 ± 5*	91 ± 5	63 ± 4***

^$P < 0.05 versus adult-c group, *P < 0.05, **P < 0.01, ***P < 0.001 versus before treatment in the same group

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