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Table 2 Changes in anthropometric and metabolic variables over time in patients with normal and high baseline ALT completing the milk programme

From: Changes in alanine aminotransferase in adults with severe and complicated obesity during a milk-based meal replacement programme

  Week 0 Week 2 Week 4 Week 6 Week 8 Week 16 Week 24 p
ALT (iu/L)a 25 [20.0,37.3] 38 [26.0,53.5] 39 [26.0,60.0] 35 [26.0,49.0] 32 [23.0,41.3] 24 [19.0,34.3] 21 [17.0,28.3] < 0.0005
ALT (iu/L)ab 41.0 [33.0,62.5] 50.0 [40.5,85.0] 50.5 [39.5,68.3] 41.0 [34.0,67.3] 39.0 [32.0,51.0] 34.5 [25.0,41.3] 26.5 [21.0,36.5] < 0.0005
ALT normal (iu/L)ac 20.5 [17.0,24.0] 29.5 [20.3,41.0] 28.5 [20.3,43.0] 27.0 [21.3,38.5] 26.0 [18.3,36.0] 20.0 [17.0,25.0] 19.0 [16.0,22.0] < 0.0005
Weight (kg) 144.2 ± 28.0 137.6 ± 27.4 134.1 ± 27.0 131.0 ± 26.2 128.3 ± 25.6 123.0 ± 25.0 121.6 ± 25.4 < 0.0005
BMI (kg m2) 50.7 ± 8.1 47.4 ± 10.4 45.4 ± 12.0 44.5 ± 12.0 45.2 ± 7.6 43.2 ± 7.5 43.0 ± 7.6 < 0.0005
EBW (%) 103.1 ± 32.4 89.6 ± 42.0 81.6 ± 48.2 78.3 ± 47.4 81.0 ± 30.6 73.0 ± 30.0 71.0 ± 31.0 < 0.0005
HbA1c (mmol/mol)d 39.3 ± 4.0 37.6 ± 4.0 37.0 ± 4.0 36.3 ± 4.0 36.0 ± 4.2 35.4 ± 3.3 35.3 ± 3.5 < 0.0005
HbA1c (mmol/mol)e 67.2 ± 13.3 62.2 ± 13.0 59.0 ± 13.0 56.0 ± 14.2 54.0 ± 15.0 48.5 ± 14.4 48.6 ± 14.1 < 0.0005
LDL (mmol/L) 2.6 ± 1.0 2.2 ± 1.0 2.1 ± 0.7 2.2 ± 1.0 2.2 ± 1.0 2.5 ± 1.0 2.6 ± 1.0 < 0.0005
HDL (mmol/L) 1.2 ± 0.4 1.1 ± 0.3 1.1 ± 0.3 1.1 ± 0.3 1.1 ± 0.3 1.2 ± 0.3 1.3 ± 0.4 < 0.0005
Triglyceride (mmol/L) 1.8 ± 0.7 1.5 ± 0.6 1.4 ± 0.5 1.4 ± 0.5 1.3 ± 0.5 1.3 ± 0.5 1.3 ± 0.5 < 0.0005
Total cholesterol (mmol/L) 4.6 ± 1.0 3.9 ± 1.0 3.7 ± 1.0 3.8 ± 1.0 4.0 ± 1.0 4.2 ± 1.0 4.4 ± 1.0 < 0.0005
  1. Values are presented as Mean ± SD
  2. aDenotes variables that are not normally distributed presented as median [IQR]
  3. bDenotes variables that represent values higher than normal at the start of the programme
  4. cDenotes variables that represent values that were normal at the start of the programme
  5. dDenote patients without history of type 2 diabetes
  6. eDenote patients with history of type 2 diabetes