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Table 3 ORs and 95% Cls for quartiles of dietary nutrients intake with risk of cervical intraepithelial neoplasia grades 2 and above among 2304 women in the studya

From: Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study

  Quartiles of dietary nutrientsb
Q1 Q2 Q3 Q4 P-trendc
Folate      
 Median intake (μg/day) 297 381 488 764  
 No. of cases 75 57 49 56  
 Model 1 1.35 (0.93–1.97) 1.04 (0.70–1.54) 0.85 (0.56–1.28) 1.00 (reference) < 0.001
 Model 2 1.49 (1.01–2.21) 1.08 (0.72–1.62) 0.89 (0.58–1.35) 1.00 (reference) < 0.001
 Model 3 1.55 (1.03–2.33) 1.18 (0.77–1.79) 0.94 (0.61–1.46) 1.00 (reference) 0.008
Vitamin B1      
 Median intake (mg/day) 1.1 1.4 1.9 2.7  
 No. of cases 72 72 35 58  
 Model 1 1.24 (0.84–1.82) 1.41 (0.96–2.06) 0.59 (0.39–0.90) 1.00 (reference) < 0.001
 Model 2 1.29 (0.86–1.93) 1.34 (0.90–1.99) 0.55 (0.36–0.84) 1.00 (reference) < 0.001
 Model 3 1.49 (0.97–2.28) 1.34 (0.89–2.04) 0.56 (0.36–0.87) 1.00 (reference) 0.017
Vitamin B2      
 Median intake (mg/day) 1.1 1.4 1.8 2.7  
 No. of cases 62 63 51 61  
 Model 1 0.95 (0.65–1.39) 1.07 (0.73–1.57) 0.83 (0.56–1.23) 1.00 (reference) < 0.001
 Model 2 1.07 (0.72–1.58) 1.12 (0.75–1.66) 0.92 (0.61–1.38) 1.00 (reference) < 0.001
 Model 3 1.18 (0.78–1.77) 1.11 (0.73–1.68) 0.96 (0.63–1.47) 1.00 (reference) 0.011
Vitamin B6      
 Median intake (mg/day) 1.7 2.1 2.6 3.9  
 No. of cases 69 65 47 56  
 Model 1 1.27 (0.87–1.86) 1.13 (0.77–1.66) 0.83 (0.55–1.25) 1.00 (reference) < 0.001
 Model 2 1.42 (0.96–2.11) 1.18 (0.79–1.75) 0.87 (0.57–1.32) 1.00 (reference) < 0.001
 Model 3 1.63 (1.08–2.46) 1.33 (0.88–2.01) 0.93 (0.60–1.44) 1.00 (reference) 0.002
Vitamin C      
 Median intake (mg/day) 46.0 62.8 86.9 138.9  
 No. of cases 73 56 57 51  
 Model 1 1.44 (0.98–2.11) 1.13 (0.76–1.70) 1.14 (0.76–1.71) 1.00 (reference) < 0.001
 Model 2 1.56 (1.05–2.33) 1.16 (0.76–1.76) 1.15 (0.76–1.75) 1.00 (reference) < 0.001
 Model 3 1.59 (1.05–2.42) 1.16 (0.75–1.79) 1.11 (0.72–1.71) 1.00 (reference) 0.008
Vitamin E      
 Median intake (mg/day) 4.4 8.8 10.8 21.7  
 No. of cases 50 67 59 61  
 Model 1 0.76 (0.51–1.13) 1.03 (0.71–1.50) 1.02 (0.69–1.50) 1.00 (reference) < 0.001
 Model 2 0.92 (0.61–1.40) 1.13 (0.77–1.66) 1.08 (0.72–1.60) 1.00 (reference) < 0.001
 Model 3 0.93 (0.60–1.43) 1.29 (0.86–1.93) 1.04 (0.69–1.58) 1.00 (reference) 0.011
Vitamin K      
 Median intake (μg/day) 133.0 194.0 285.0 534.0  
 No. of cases 61 71 51 54  
 Model 1 1.12 (0.77–1.65) 1.42 (0.96–2.10) 1.01 (0.68–1.50) 1.00 (reference) < 0.001
 Model 2 1.20 (0.81–1.79) 1.53 (1.02–2.29) 1.05 (0.70–1.58) 1.00 (reference) < 0.001
 Model 3 1.30 (0.86–1.98) 1.60 (1.05–2.44) 1.24 (0.81–1.89) 1.00 (reference) 0.009
Niacin      
 Median intake (mg/day) 17.7 21.6 27.9 42.8  
 No. of cases 68 60 54 55  
 Model 1 1.30 (0.88–1.92) 1.08 (0.73–1.59) 1.02 (0.69–1.51) 1.00 (reference) < 0.001
 Model 2 1.40 (0.94–2.09) 1.14 (0.76–1.70) 0.98 (0.65–1.47) 1.00 (reference) < 0.001
 Model 3 1.65 (1.08–2.51) 1.32 (0.87–2.01) 1.09 (0.71–1.66) 1.00 (reference) 0.009
Dietary fiber      
 Median intake (g/day) 27.4 34.5 43.7 63.2  
 No. of cases 68 64 49 56  
 Model 1 1.23 (0.84–1.81) 1.18 (0.80–1.73) 0.84 (0.56–1.26) 1.00 (reference) < 0.001
 Model 2 1.31 (0.88–1.95) 1.18 (0.79–1.76) 0.80 (0.53–1.22) 1.00 (reference) < 0.001
 Model 3 1.50 (0.99–2.27) 1.16 (0.76–1.76) 0.87 (0.56–1.34) 1.00 (reference) 0.009
  1. CIN1, cervical intraepithelial neoplasia grade 1; CI confidence interval
  2. aValues are n or ORs (95% CIs) obtained from logistic regression analysis, based on the highest intake group as the reference, unless otherwise indicated
  3. bModel 1: odds ratios unadjusted; Model 2: odds ratios adjusted for age, education years, annual family salary, smoker, age at menarche, menopause status, IUD use, years of IUD use, Sexual activity in menstrual period, had gynecologic surgery, had vaginitis; Model 3: additionally odds ratios adjusted for high-risk HPV, SCJ visibility, vaginal pH
  4. cP values for differences between groups were obtained from the Bonferroni correction test for categoric variables