Skip to main content

Table 1 Patient demographics, sorted by clinical response

From: Differential ketogenic diet-induced shift in CSF lipid/carbohydrate metabolome of pediatric epilepsy patients with optimal vs. no anticonvulsant response: a pilot study

Characteristics of 5 patients with optimal seizure reduction (no detected seizures)
 sex age Epilepsy type(s) Seizure type(s) Etiology/syndrome AEDs Diet ratio
 M 4.5 generalized Myoclonic, generalized T/C Doose syndrome VPA, CZP 4:1
 F 4.8 generalized Myoclonic, tonic, absence L-G syndrome CLB 3:1
 M 5.1 generalized Myoclonic, tonic Down’s syndrome VPA, LTG 4:1
 F 5.8 generalized Myoclonic, generalized T/C Cortical dysplasia (polymicrogyria) none 3:1
 F 9.0 focal Focal without impaired awareness Cortical dysplasia PRI, VPA 4:1
 Mean: 5.8      
Characteristics of 5 patients with no observed change in seizures
 M 4.0 generalized Myoclonic, tonic, epileptic spasms Inverted duplicated chromosome 15, L-G syndrome LTG, TPM 4:1
 M 6.0 generalized Epileptic spasms, generalized T/C L-G syndrome VPA, LTG 3:1
 M 6.3 generalized Myoclonic, absence, generalized T/C Infantile spasms, L-G syndrome VPA, CLB 4:1
 F 6.7 generalized Generalized T/C Unknown LTG, PB, TPM 4:1
 M 10.1 generalized Myoclonic, atonic Agenesi corpus callosum, other CNS malformations VPA, CZP 4:1
 Mean: 6.6      
  1. Seizure types classified according to the International League Against Epilepsy (ILAE) classification [31]. “Diet ratio” indicates the (fat:(protein + carbohydrate)) ratio of the KD at time of 2nd lumbar puncture. Abbreviations: AED antiepileptic drug, T/C tonic/clonic, L-G Lennox-Gastaux syndrome, VPA valproic acid, CZP clonazepam, CLB clobazam, LTG lamotrigine, PRI primidone, TPM topiramate, PB phenobarbital