|
Compound Family
|
Compound
|
optimal response
|
no response
|
|
Ketone Bodies
|
1,2-propanediol
|
29.16***
|
7.47**
|
|
Acetoacetate
|
130.8***
|
67.5***
|
|
β-hydroxybutyrate
|
175.5***
|
57.4***
|
|
Acyl Carnitines
|
Propionyl-carnitine
|
1.50*
|
1.48
|
|
Acetyl-carnitine
|
5.19***
|
3.89*
|
|
Butyryl-carnitine
|
5.51**
|
2.40
|
|
Octanoyl-carnitine
|
9.43***
|
5.44
|
|
Hexanoyl-carnitine
|
16.09***
|
4.73**
|
|
3-hydroxybutyryl-carnitine
|
23.63***
|
15.84**
|
|
Carnitine Metabolism
|
Carnitine
|
0.99
|
1.19
|
|
Deoxycarnitine
|
2.00
|
1.35
|
|
3-dehydrocarnitine
|
61.96***
|
108.5***
|
|
Monohydroxy Fatty Acids
|
2-hydroxyhexanoate
|
1.28
|
2.10
|
|
3-hydroxypropanoate
|
2.35
|
1.46
|
|
γ-hydroxybutyrate
|
3.40***
|
2.06**
|
|
5-hydroxyhexanoate
|
6.48*
|
2.29*
|
|
3-hydroxyoctanoate
|
10.35***
|
3.48***
|
|
3-hydroxysebacate
|
22.12**
|
6.70
|
|
Medium Chain Fatty Acids
|
Nonanoic acid
|
0.97
|
1.19
|
|
Dodecanoic acid
|
1.05
|
0.98
|
|
Decanoic acid
|
1.14*
|
1.12
|
|
Octanoic acid
|
1.90
|
1.15
|
|
Heptanoic acid
|
2.24
|
0.73
|
|
Hexanoic acid
|
3.29
|
1.49
|
|
Phospholipid Metabolism
|
Choline
|
0.96
|
0.94
|
|
Phosphoethanolamine
|
1.02
|
1.26
|
|
Choline phosphate
|
1.47
|
2.50
|
|
Trimethylamine N-oxide
|
715.1**
|
375.3**
|
|
Amide Fatty Acid
|
Oleamide
|
0.99
|
16.48
|
|
Dicarboxylate Fatty Acids
|
2-hydroxyglutarate
|
2.05
|
1.07
|
|
CMPF
|
8.81*
|
2.61
|
|
Triglyceride Metabolism
|
Glycerol 3-phosphate
|
0.82**
|
0.86
|
|
Glycerol
|
1.22
|
0.89
|
|
Lysophospholipids
|
1-oleoyl-GPC (18:1)
|
0.46*
|
2.27
|
|
1-docosahexaenoyl-GPE (22:6)
|
0.93
|
0.84
|
|
1-oleoyl-GPE (18:1)
|
1.29
|
1.51
|
|
1-palmitoyl-GPC (16:0)
|
3.16
|
1.90
|
|
Inositol Metabolism
|
Scyllo-inositol
|
0.84
|
0.81
|
|
Myo-inositol
|
1.12
|
0.81
|
|
Amino Fatty Acids
|
2-aminoheptanoate
|
1.38
|
1.67
|
|
2-aminooctanoate
|
631.4
|
9.24*
|
|
Fatty Acid Synthesis
|
2-methylmalonylcarnitine
|
0.64***
|
0.69*
|
|
Polyunsaturated Fatty Acid
|
Docosahexaenoate (22:6n3)
|
2.05
|
1.07
|
|
Primary Bile Acid Metabolism
|
Glycocholate
|
12.08*
|
2.44
|
|
Sphingolipid Metabolism
|
Palmitoyl sphingomyelin (d18:1/16:0)
|
2.66*
|
1.73
|
|
Corticosteroids
|
Cortisone
|
0.73**
|
1.19
|
|
Cortisol
|
0.98
|
1.65
|
|
Androgenic Steroid
|
Androstenediol (3β,17β) disulfate
|
6.31
|
6.02
|
|
Sterols
|
7-α-HOCA
|
0.95
|
0.88*
|
