Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Nutrition & Metabolism

Table 7 Correlation between serum lipid parameters and the SLC44A4 rs577272 SNP and NOTCH4 rs3134931 SNP alleles/genotypes in the Han and Maonan populations

Lipid	SNP	Allele	Genotype	Std.error	Beta	t	P
Han + Maonan
TC	rs577272	A/G		0.009	− 0.027	− 3.169	0.002
	rs577272		AA/GA/GG	0.019	0.065	3.394	0.001
TG	rs3134931	G/A		0.068	− 0.236	− 3.495	4.92E−4
			GG/AG/AA	0.077	− 0.212	− 2.749	0.006
HDL-C	rs577272		AA/GA/GG	0.043	0.112	2.580	0.010
LDL-C	rs3134931		AA/GA/GG	0.021	− 0.071	− 3.395	0.001
Han
TC	rs577272	A/G		0.065	0.117	2.717	0.007
TG	rs3134931	G/A		0.068	− 0.236	− 3.495	4.913E−4
			GG/AG/AA	0.019	0.065	3.394	0.001
HDL-C	rs3134931	G/A		0.091	− 0.359	− 3.958	7.95E−5
	rs577272	A/G		0.137	0.276	2.014	0.044
Maonan
TC	rs577272	A/G		0.092	0.527	6.103	9.24E−10
	rs577272		AA/GA/GG	0.069	− 0.305	− 4.437	9.33E−6
TG	rs3134931	G/A		0.064	− 0.199	− 3.091	0.004
	rs3134931		AA/GA/GG	0.049	− 0.128	− 2.628	0.008
HDL-C	rs577272		AA/GA/GG	0.035	− 0.119	− 3.754	1.83E−4
	rs577272	A/G		0.058	− 0.16	− 2.725	0.006
	rs3134931	G/A		0.031	− 0.094	− 3.236	0.002
LDL-C	rs3134931		AA/GA/GG	0.093	0.567	6.123	9.04E−10
	rs3134931	G/A		0.069	− 0.305	− 4.417	4.83E−6

Association of serum lipid traits and allele and genotypes in Maonan, Han and combined the Maonan and Han populations were assessed by multivariable linear regression analyses with stepwise modeling
TC total cholesterol, HDL-C high-density lipoprotein cholesterol, Apo apolipoprotein, Beta standardized coefficient

ISSN: 1743-7075