Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Zheng, Peng-Fei; Yin, Rui-Xing; Guan, Yao-Zong; Wei, Bi-Liu; Liu, Chun-Xiao; Deng, Guo-Xiong

doi:10.1186/s12986-020-00533-0

Nutrition & Metabolism

Table 8 Relationship between serum lipid parameters and relative factors in the Han and Maonan populations

From: Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Lipid	Risk factor	B	Std.error	Beta	t	P
Han and Maonan
TC	Waist circumference	0.021	0.003	0.173	7.626	3.63E−4
	Diastolic blood pressure	0.010	0.002	0.117	5.290	1.35E−7
	Age	0.007	0.002	0.086	3.962	7.69E−5
	Height	− 0.013	0.003	− 0.094	− 3.923	9.02E−5
	Cigarette smoking	0.130	0.050	0.059	2.610	0.009
	Ethnic group	0.103	0.045	0.048	2.285	0.022
TG	Pulse pressure	− 0.004	0.001	0.072	− 3.311	0.001
	Cigarette smoking	− 0.116	0.056	0.055	− 2.068	0.039
	Height	− 0.010	0.003	− 0.093	− 3.596	3.30E−4
HDL-C	Ethnic group	− 0.194	0.023	− 0.176	− 8.325	1.49E−6
	Weight	0.005	0.001	0.090	− 3.921	9.10E−5
	Gender	0.089	0.026	0.079	3.420	0.001
LDL-C	Waist circumference	0.018	0.002	0.190	8.407	7.62E−17
	Alcohol consumption	− 0.209	0.033	− 0.156	− 6.379	2.19E−10
	Ethnic group	− 0.004	0.001	− 0.100	− 3.758	1.76E−4
ApoA1	Alcohol consumption	0.131	0.011	0.280	11.464	1.46E−9
	Cigarette smoking	0.117	0.016	0.192	7.441	1.44E−13
	Weight	− 0.002	0.001	− 0.074	− 2.269	0.023
	Waist circumference	− 0.002	0.001	− 0.074	− 2.399	0.017
ApoB	Waist circumference	0.007	0.001	0.294	13.301	7.78E−9
	Systolic blood pressure	0.001	0.000	0.100	4.735	2.34E−6
	Height	− 0.002	0.001	− 0.052	− 2.417	0.016
ApoA1/ApoB	Waist circumference	− 0.019	0.001	− 0.274	− 13.042	1.87E−37
	Alcohol consumption	0.160	0.024	0.166	6.711	2.47E−11
	Cigarette smoking	0.167	0.033	0.134	5.132	3.12E−7
Han
TC	Diastolic blood pressure	0.017	0.003	0.192	6.289	4.70E−10
	Waist circumference	0.016	0.004	0.121	3.823	1.40E−4
	Glucose	0.056	0.019	0.087	2.919	0.004
	Gender	− 0.010	0.005	− 0.076	− 2.265	0.024
TG	Glucose	0.036	0.016	0.068	2.225	0.026
	Cigarette smoking	− 0.125	0.051	− 0.075	− 2.449	0.014
	Pulse pressure	− 0.007	0.002	− 0.138	− 4.510	7.21E−6
HDL-C	Weight	− 0.015	0.002	− 0.238	− 7.359	3.74E−4
	Alcohol consumption	0.097	0.028	0.113	3.501	4.83E−4
	Gender	− 0.005	0.002	− 0.098	− 2.538	0.011
LDL-C	Waist circumference	0.016	0.003	0.148	4.846	1.45E−6
	Systolic blood pressure	0.008	0.002	0.194	5.417	7.53E−8
	Age	− 0.006	0.001	− 0.147	− 4.213	2.73E−5
ApoA1	Alcohol consumption	0.189	0.014	0.423	13.732	1.38E−9
	Cigarette smoking	0.143	0.017	0.255	8.598	2.90E−7
	Weight	− 0.006	0.001	− 0.174	− 6.225	6.93E−10
ApoB	Waist circumference	0.006	0.001	0.224	5.731	1.30E−8
	Glucose	0.012	0.004	0.092	3.165	0.002
	BMI	0.005	0.002	0.085	2.227	0.026
ApoA1/ApoB	Waist circumference	− 0.013	0.003	− 0.168	− 3.744	1.91E−4
	Alcohol consumption	0.204	0.033	0.222	6.239	6.39E−10
	Cigarette smoking	0.204	0.043	0.176	4.798	1.84E−6
Maonan
TC	Waist circumference	0.023	0.004	0.202	6.206	0.000
	Age	0.007	0.002	0.103	3.302	0.001
	Diastolic blood pressure	0.005	0.003	0.062	1.966	0.050
	Height	− 0.010	0.005	− 0.076	− 2.265	0.024
TG	Alcohol consumption	0.178	0.060	0.108	2.980	0.003
	Cigarette smoking	− 0.183	0.086	− 0.082	− 2.125	0.034
	Weight	− 0.015	0.002	− 0.238	− 7.359	3.74E−13
HDL-C	Gender	0.158	0.042	0.143	3.783	1.64E−4
	Systolic blood pressure	0.002	0.001	0.087	2.835	0.005
LDL-C	Alcohol consumption	− 0.310	0.039	− 0.231	− 7.920	5.92E−5
	Waist circumference	0.017	0.003	0.194	6.633	5.21E−5
	Age	0.008	0.002	0.140	4.856	1.38E−6
ApoA1	Waist circumference	− 0.004	0.001	− 0.143	− 4.708	2.83E−6
	Alcohol consumption	0.071	0.015	0.147	4.855	1.38E−6
	Glucose	0.014	0.06	0.067	− 2.227	0.026
ApoB	Waist circumference	0.007	0.001	0.297	9.806	8.51E−6
	Age	0.001	0.000	0.071	2.197	0.028
	Pulse pressure	0.001	0.000	0.070	2.133	0.033
ApoA1/ApoB	Waist circumference	− 0.017	0.002	− 0.261	− 8.784	6.16E−8
	Alcohol consumption	0.161	0.029	0.163	5.552	3.56E−8
	Pulse pressure	− 0.003	0.001	− 0.095	− 3.234	0.001

TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B, B unstandardized coefficient, Beta standardized coefficient

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ISSN: 1743-7075

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