Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Zheng, Peng-Fei; Yin, Rui-Xing; Guan, Yao-Zong; Wei, Bi-Liu; Liu, Chun-Xiao; Deng, Guo-Xiong

doi:10.1186/s12986-020-00533-0

Nutrition & Metabolism

Table 9 Relationship between serum lipid parameters and relative factors in the males and females of the Han and Maonan populations

From: Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Lipid	Risk factor	B	Std.error	Beta	t	P
Han/male
TC	Waist circumference	0.016	0.006	0.123	2.640	0.009
	Glucose	0.060	0.028	0.098	2.126	0.034
TG	BMI	0.006	0.003	0.111	2.073	0.037
	Weight	− 0.015	0.005	− 0.222	− 3.139	0.002
HDL-C	Weight	− 0.018	0.003	− 0.307	− 6.477	2.54E−10
	Alcohol consumption	0.102	0.031	0.158	3.327	0.001
LDL-C	Cigarette smoking	− 0.187	0.064	− 0.137	− 2.911	0.004
	BMI	0.031	0.010	0.142	3.052	0.002
	Glucose	0.057	0.024	0.114	2.420	0.016
ApoA1	Alcohol consumption	0.197	0.015	0.519	12.809	4.48E−7
	Weight	− 0.005	0.001	− 0.142	− 3.648	2.97E−4
ApoB	Waist circumference	0.007	0.001	0.262	4.837	1.83E−6
	Glucose	0.020	0.006	0.152	3.472	0.001
ApoA1/ApoB	Waist circumference	− 0.011	0.005	− 0.147	− 2.121	0.035
	Alcohol consumption	0.221	0.034	0.300	6.572	1.44E−9
Han/female
TC	Systolic blood pressure	0.011	0.003	0.192	3.394	0.001
	Age	0.009	0.003	0.106	2.437	0.015
TG	Height	− 0.014	0.006	− 0.091	− 2.242	0.025
	Waist circumference	0.019	0.006	0.128	3.055	0.002
HDL-C	Waist circumference	− 0.011	0.003	− 0.142	− 3.563	3.95E−4
	Pulse pressure	0.002	0.001	0.109	2.803	0.005
LDL-C	Systolic blood pressure	0.005	0.002	0.107	2.566	0.011
	Waist circumference	0.018	0.005	0.149	3.745	1.91E−4
ApoA1	Cigarette smoking	0.317	0.057	0.215	5.558	4.07E−8
	Weight	− 0.005	0.001	− 0.152	− 3.907	1.04E−4
ApoB	Waist circumference	0.007	0.001	0.240	6.191	1.09E−9
	Pulse pressure	0.002	0.001	0.141	3.643	2.92E−4
ApoA1/ApoB	Waist circumference	− 0.016	0.003	− 0.202	− 5.172	3.14E−7
	Cigarette smoking	0.580	0.137	0.165	4.225	2.75E−5
Maonan/male
TC	Waist circumference	− 0.012	0.001	− 0.276	− 8.270	5.04E−6
	Alcohol consumption	0.131	0.023	0.206	5.594	2.98E−8
TG	Waist circumference	− 0.019	0.002	− 0.311	− 9.736	2.53E−7
	Weight	0.010	0.004	0.114	2.541	0.005
	Genotype	− 0.06	0.026	− 0.073	− 2.313	0.021
HDL-C	Pulse pressure	− 0.002	0.001	− 0.078	− 2.202	0.028
	Alcohol consumption	0.057	0.048	0.113	3.801	5.23E−4
LDL-C	Weight	0.013	0.004	0.170	3.589	3.61E−4
	Alcohol consumption	0.121	0.022	0.265	5.579	4.48E−8
ApoA1	Waist circumference	− 0.007	0.002	− 0.165	− 3.486	0.001
	Glucose	− 0.026	0.012	− 0.103	− 2.163	0.031
ApoB	Alcohol consumption	− 0.029	0.011	− 0.122	− 2.670	0.008
	Age	0.001	0.001	0.095	2.000	0.046
ApoA1/ApoB	Waist circumference	− 0.021	0.003	− 0.293	− 6.435	3.56E−10
	Glucose	− 0.043	0.021	− 0.093	− 2.032	0.043
Maonan/female	Age	0.015	0.003	0.193	4.788	2.08E−6
TC	Waist circumference	0.019	0.005	0.153	3.852	1.28E−4
	Glucose	− 0.077	0.031	− 0.095	− 2.459	0.014
TG	BMI	0.156	0.049	0.122	3.183	0.002
	Alcohol consumption	0.471	0.165	0.109	2.862	0.004
HDL-C	Weight	0.002	0.001	0.093	2.676	0.008
	Alcohol consumption	− 1.066	0.152	− 0.252	− 7.014	5.68E−12
LDL-C	Waist circumference	0.022	0.003	0.242	6.552	1.13E−10
	Alcohol consumption	− 0.312	0.044	− 0.260	− 7.023	5.35E−12
ApoA1	BMI	− 0.006	0.002	− 0.100	− 2.708	0.007
	Waist circumference	0.496	0.042	0.399	11.810	2.27E−9
ApoB	Waist circumference	0.005	0.001	0.185	5.353	1.19E−7
	Alcohol consumption	− 0.687	0.101	− 0.243	− 6.786	2.54E−11
ApoA1/ApoB	Waist circumference	− 0.011	0.002	− 0.182	− 4.942	9.79E−7

The correlation among serum lipid parameters and the genotypes and several environmental factors was determined by multivariable linear regression analyses with stepwise modeling
TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B, B unstandardized coefficient, Beta standardized coefficient

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ISSN: 1743-7075

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