Fig. 1

S-Equol improves hyperglycemia and hyperlipemia in ZDF rats. The ZDF rats were treated with or without Equol (120 mg/kg.BW.d) for six weeks, and ZLR rats were used as the control. Body weight (a), water intake (b), food intake (c), fasting blood glucose (d), OGTT test after 2-week (e), 4-week (f) and 6-week (g) treatment and the AUC of glucose level (h), total cholesterol (i), triglyceride (j), LDL-c(k) and HDL-c (I) were assessed. Eq, Equol; ZDF, Zucker diabetic fatty rats (fa/fa); ZLR, Zucker lean rats (fa/+); OGTT, oral glucose tolerance test; AUC, areas under the curve; LDL, low density lipoprotein; HDL, high density lipoprotein. Data are presented as mean ± S. D (n = 6), ^# P < 0.05 vs. the ZLR group; * P < 0.05 vs. the ZDF group