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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3)

Fig. 2

Ascorbate reduces lipid accumulaion and repairs insulin signal transduction in hepatic cells. With administration of various concentration of PA for 12 h, HepG2 cells were detected (a) intracellular TG content (n = 4) and (b) CCK8 absorbance for viability (n = 3) respectively. Significance was compared with control. HepG2 cells were treated with 0.5 mM PA for various interval, lysates of cells were collected to detect (c) intracellular TG content (n = 4). Significance was compared with PA group at each time point. HepG2 cells were co-treated with PA and ascorbate for 48 h, detected (d) intracellular TG content (n = 6) and (e) CCK8 absorbance for viability (n = 4). f Western blotting for phosphoryl level of proteins involved in insulin signaling pathway. Statistical significance was assessed with one way ANOVA

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