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Fig. 7 | Nutrition & Metabolism

Fig. 7

From: Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis

Fig. 7

High-fat diet-induced ER stress-mediated pyroptosis and olive oil ameliorated this effect in a rat NAFLD model. a. H&E staining of liver sections from chow, HFD, HFD/OA and OA groups(N = 5). b. and c. Changes in liver weights and volume at the end of 32 w treatment. d. Changes in body weights of experimental animals from different groups. e-j. Serum levels of AST, AST, TG, TC,LDL-C and HDL-C. k. Scores of steatosis based on the representative H&E staining of liver sections from different groups. Grades of steatosis: 0 (no steatosis), 1 (< 33% steatosis), 2 (33–66% steatosis) or 3 (> 66% steatosis) (n = 5). l. and m. Representative western blots of ER stress and pyroptosis makers, and β-ACTIN was used as a protein-loading control. The data are presented as means ± SD for 3–5 biological replicates; *P < 0.05, **P < 0.01, and ***P < 0.001vs. Chow; #P < 0.05, ##P < 0.01, vs. HFD;ns no significant differences between two connected groups

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