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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Fig. 5

SIRT1-regulated autophagy is mechanistically involved in ferulic acid-alleviated lipotoxicity. AML-12 cells were transfected with si-SIRT1 or scramble siRNA before ferulic acid (FA) exposure. FA (100 μM) was added 2 h before 0.5 mM palmitic acid (PA) exposure (12 h). a, b LDH release and caspase-3 cleavage were detected. c Nuclear morphology was observed by Hoechst staining. All values are shown as the means ± SD from three or more independent batches of cells. Bars with different superscripts are significantly different at p ˂ 0.05

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Nutrition & Metabolism

ISSN: 1743-7075

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