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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Fig. 6

Ferulic acid improves PA-induced proinflammatory cytokines activation in hepatocytes. AML-12 cells were pretreated with or without ferulic acid (FA, 100 μM) for 2 h before 12 h of palmitic acid (PA, 0.5 mM) exposure. Chloroquine (CQ, 20 μM) was added 1 h before FA exposure. For SIRT1 silencing, treatments were carried out after transfecting cells with si-SIRT1 or scramble siRNA. Gene expression of proinflammatory factors was analysed by quantitative real-time PCR. a, b IL-6 mRNA. c, d IL-1β mRNA. All values are shown as the means ± SD from three or more independent batches of cells. Bars with different superscripts are significantly different at p ˂ 0.05

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