TY - JOUR AU - Oh, Y. S. AU - Bae, G. D. AU - Baek, D. J. AU - Park, E. Y. AU - Jun, H. S. PY - 2018 DA - 2018// TI - Fatty acid-induced lipotoxicity in pancreatic beta cells during development of type 2 diabetes JO - Front Endocrinol VL - 9 UR - https://doi.org/10.3389/fendo.2018.00384 DO - 10.3389/fendo.2018.00384 ID - Oh2018 ER - TY - JOUR AU - Maedler, K. AU - Oberholzer, J. AU - Bucher, P. AU - Spinas, G. A. AU - Donath, M. Y. PY - 2003 DA - 2003// TI - Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function JO - Diabetes VL - 52 UR - https://doi.org/10.2337/diabetes.52.3.726 DO - 10.2337/diabetes.52.3.726 ID - Maedler2003 ER - TY - JOUR AU - Poitout, V. AU - Amyot, J. AU - Semache, M. AU - Zarrouki, B. AU - Hagman, D. AU - Fontes, G. PY - 2010 DA - 2010// TI - Glucolipotoxicity of the pancreatic β-cell JO - Biochim Biophys Acta VL - 1801 ID - Poitout2010 ER - TY - JOUR AU - Zheng, Y. AU - Ley, S. H. AU - Hu, F. B. PY - 2018 DA - 2018// TI - Global aetiology and epidemiology of type 2 diabetes and its complications JO - Nat Rev Endocrinol VL - 14 UR - https://doi.org/10.1038/nrendo.2017.151 DO - 10.1038/nrendo.2017.151 ID - Zheng2018 ER - TY - JOUR AU - Cao, H. PY - 2014 DA - 2014// TI - Adipocytokines in obesity and metabolic disease JO - J Endocrinol VL - 220 UR - https://doi.org/10.1530/JOE-13-0339 DO - 10.1530/JOE-13-0339 ID - Cao2014 ER - TY - JOUR AU - Shimobayashi, M. AU - Albert, V. AU - Woelnerhanssen, B. AU - Frei, I. C. AU - Weissenberger, D. AU - Meyer-Gerspach, A. C. PY - 2018 DA - 2018// TI - Insulin resistance causes inflammation in adipose tissue JO - J Clin Investig VL - 128 UR - https://doi.org/10.1172/JCI96139 DO - 10.1172/JCI96139 ID - Shimobayashi2018 ER - TY - JOUR AU - Welters, H. J. AU - Tadayyon, M. AU - Scarpello, J. H. AU - Smith, S. A. AU - Morgan, N. G. PY - 2004 DA - 2004// TI - Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure JO - FEBS Lett VL - 560 UR - https://doi.org/10.1016/S0014-5793(04)00079-1 DO - 10.1016/S0014-5793(04)00079-1 ID - Welters2004 ER - TY - JOUR AU - Diakogiannaki, E. AU - Dhayal, S. AU - Childs, C. E. AU - Calder, P. C. AU - Welters, H. J. AU - Morgan, N. G. PY - 2007 DA - 2007// TI - Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells JO - J Endocrinol VL - 194 UR - https://doi.org/10.1677/JOE-07-0082 DO - 10.1677/JOE-07-0082 ID - Diakogiannaki2007 ER - TY - JOUR AU - Hellemans, K. H. AU - Hannaery, J. C. AU - Denys, B. AU - Steffensen, K. R. AU - Raemdonck, C. AU - Martens, G. A. AU - Veldhoven, P. P. AU - Gustafsson, J. A. AU - Pipeleers, D. PY - 2009 DA - 2009// TI - Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPAR α-dependent Stearoyl-Conenzyme A desaturase JO - PLoS ONE VL - 4 UR - https://doi.org/10.1371/journal.pone.0007266 DO - 10.1371/journal.pone.0007266 ID - Hellemans2009 ER - TY - JOUR AU - Plötz, T. AU - Krummel, B. AU - Pingitore, A. AU - Persaud, S. J. AU - Elsner, M. AU - Mehmeti, I. AU - Lenzen, S. PY - 2017 DA - 2017// TI - The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human β-cells JO - Nutr Diabetes VL - 7 UR - https://doi.org/10.1038/s41387-017-0005-x DO - 10.1038/s41387-017-0005-x ID - Plötz2017 ER - TY - JOUR AU - Richardson, S. J. AU - Willcox, A. AU - Bone, A. J. AU - Foulis, A. K. AU - Morgan, N. G. PY - 2009 DA - 2009// TI - Islet-associated macrophages in type 2 diabetes JO - Diabetologia VL - 52 UR - https://doi.org/10.1007/s00125-009-1410-z DO - 10.1007/s00125-009-1410-z ID - Richardson2009 ER - TY - JOUR AU - Leslie, K. A. AU - Russell, M. A. AU - Taniguchi, K. AU - Richardson, S. J. AU - Morgan, N. G. PY - 2019 DA - 2019// TI - The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes JO - Diabetologia VL - 62 UR - https://doi.org/10.1007/s00125-018-4750-8 DO - 10.1007/s00125-018-4750-8 ID - Leslie2019 ER - TY - JOUR AU - Gurgul-Convey, E. AU - Mehmeti, I. AU - Plotz, T. AU - Jorns, A. AU - Lenzen, S. PY - 2016 DA - 2016// TI - Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines JO - Diabetologia VL - 59 UR - https://doi.org/10.1007/s00125-016-4060-y DO - 10.1007/s00125-016-4060-y ID - Gurgul-Convey2016 ER - TY - JOUR AU - Demine, S. AU - Schiavo, A. A. AU - Main-Canas, S. AU - Marchetti, P. AU - Cnop, M. AU - Eizirik, D. L. PY - 2020 DA - 2020// TI - Pro-inflammatory cytokines induce cell death inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells JO - Stem Cell Res Ther VL - 11 UR - https://doi.org/10.1186/s13287-019-1523-3 DO - 10.1186/s13287-019-1523-3 ID - Demine2020 ER - TY - JOUR AU - Boden, G. PY - 2011 DA - 2011// TI - Obesity, insulin resistance and free fatty acids JO - Curr Opin Endocrinol Diabetes Obes VL - 18 UR - https://doi.org/10.1097/MED.0b013e3283444b09 DO - 10.1097/MED.0b013e3283444b09 ID - Boden2011 ER - TY - JOUR AU - Rebelos, E. AU - Seghieri, M. AU - Natali, A. AU - Balkau, B. AU - Golay, A. AU - Piatti, P. M. AU - Lalic, N. M. AU - Laako, M. AU - Mari, A. AU - Ferrannini, E. PY - 2015 DA - 2015// TI - Influence of endogenous NEFA on β-cell function in humans JO - Diabetologia VL - 59 ID - Rebelos2015 ER - TY - JOUR AU - Liu, L. AU - Li, Y. AU - Guan, C. AU - Li, K. AU - Wang, C. AU - Feng, R. AU - Sun, C. PY - 2010 DA - 2010// TI - Free fatty acid metabolic profile and biomarkers of isolated post-challenge diabetes and type 2 diabetes mellitus based on GC-MS and multivariate statistical analysis JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 878 UR - https://doi.org/10.1016/j.jchromb.2010.08.035 DO - 10.1016/j.jchromb.2010.08.035 ID - Liu2010 ER - TY - JOUR AU - Lu, Y. AU - Wang, Y. AU - Ong, C. N. AU - Subramaniam, T. AU - Won Choi, H. AU - Yuan, J. M. AU - Koh, W. P. AU - Pan, A. PY - 2016 DA - 2016// TI - Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomic study using both LC-MS and GC-MS JO - Diabetologia VL - 59 UR - https://doi.org/10.1007/s00125-016-4069-2 DO - 10.1007/s00125-016-4069-2 ID - Lu2016 ER - TY - JOUR AU - Forouhi, N. G. AU - Koulman, A. AU - Sharp, S. J. AU - Imamura, F. AU - Kröger, J. AU - Schulze, M. B. PY - 2014 DA - 2014// TI - Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study JO - Lancet Diabetes Endocrinol VL - 10 ID - Forouhi2014 ER - TY - JOUR AU - Lean, M. E. J. AU - Leslie, W. S. AU - Barnes, A. C. AU - Brosnahan, N. AU - Thom, G. AU - McCombie, L. AU - Peters, C. AU - Zhyzhneuskaya, S. PY - 2017 DA - 2017// TI - Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial JO - Lancet VL - 391 ID - Lean2017 ER - TY - JOUR AU - Douros, J. D. AU - Tong, J. AU - D’Alessio, D. A. PY - 2019 DA - 2019// TI - The effects of bariatric surgery on islet function, insulin secretion, and glucose control JO - Endocr Rev VL - 40 UR - https://doi.org/10.1210/er.2018-00183 DO - 10.1210/er.2018-00183 ID - Douros2019 ER - TY - JOUR AU - Asfari, M. AU - Janjic, D. AU - Meda, P. AU - Li, G. AU - Halban, P. A. AU - Wollheim, C. B. PY - 1992 DA - 1992// TI - Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines JO - Endocrinology VL - 130 UR - https://doi.org/10.1210/endo.130.1.1370150 DO - 10.1210/endo.130.1.1370150 ID - Asfari1992 ER - TY - JOUR AU - Ravassard, P. AU - Hazhouz, Y. AU - Pechberty, S. AU - Bricout-Neveu, E. AU - Armanet, M. AU - Czernichow, P. AU - Scharfmann, R. PY - 2011 DA - 2011// TI - A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion JO - J Clin Investig VL - 121 UR - https://doi.org/10.1172/JCI58447 DO - 10.1172/JCI58447 ID - Ravassard2011 ER - TY - JOUR AU - Dhayal, S. AU - Morgan, N. G. PY - 2011 DA - 2011// TI - Pharmacological characterisation of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells JO - Br J Pharmacol VL - 162 UR - https://doi.org/10.1111/j.1476-5381.2010.01145.x DO - 10.1111/j.1476-5381.2010.01145.x ID - Dhayal2011 ER - TY - JOUR AU - Carta, G. AU - Murru, E. AU - Banni, S. AU - Manca, C. PY - 2017 DA - 2017// TI - Palmitic acid: physiological role, metabolism and nutritional implications JO - Front Physiol VL - 8 UR - https://doi.org/10.3389/fphys.2017.00902 DO - 10.3389/fphys.2017.00902 ID - Carta2017 ER - TY - JOUR AU - Krizhanovskii, C. AU - Kristinsson, H. AU - Elksnis, A. AU - Wang, X. AU - Gavali, H. AU - Bergsten, P. PY - 2017 DA - 2017// TI - EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium JO - Islets VL - 9 UR - https://doi.org/10.1080/19382014.2017.1296995 DO - 10.1080/19382014.2017.1296995 ID - Krizhanovskii2017 ER - TY - JOUR AU - Tsonkova, V. G. AU - Sand, F. W. AU - Wolf, X. A. AU - Grunnet, L. G. AU - Ringgaard, A. K. AU - Ingvorsen, C. PY - 2018 DA - 2018// TI - The EndoC-βH1 cell line is a valid model of human β-cells and applicable for screenings to identify novel drug target candidates JO - Mol Metab UR - https://doi.org/10.1016/j.molmet.2017.12.007 DO - 10.1016/j.molmet.2017.12.007 ID - Tsonkova2018 ER - TY - JOUR AU - Oshima, M. AU - Pechberty, S. AU - Bellini, L. AU - Göpel, S. O. AU - Campana, M. AU - Rouch, C. PY - 2019 DA - 2019// TI - Stearoyl CoA desaturase is a gatekeeper that protects human β-cell s against lipotoxicity and maintains their identity JO - Diabetologia VL - 63 ID - Oshima2019 ER - TY - JOUR AU - Plötz, T. AU - Hanstein, A. S. AU - Krümmel, B. AU - Laporte, A. AU - Mehmeti, I. AU - Lenzen, S. PY - 2019 DA - 2019// TI - Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells JO - Biochim Biophys Acta Mol Basis Dis VL - 1865 UR - https://doi.org/10.1016/j.bbadis.2019.08.001 DO - 10.1016/j.bbadis.2019.08.001 ID - Plötz2019 ER - TY - JOUR AU - Busch, A. K. AU - Gurisik, E. AU - Cordery, D. V. AU - Sudlow, M. AU - Denyer, G. S. AU - Laybutt, D. R. AU - Hughes, W. E. AU - Biden, T. J. PY - 2005 DA - 2005// TI - Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta cells from lipoapoptosis JO - Diabetes VL - 54 UR - https://doi.org/10.2337/diabetes.54.10.2917 DO - 10.2337/diabetes.54.10.2917 ID - Busch2005 ER - TY - JOUR AU - Weir, G. C. PY - 2019 DA - 2019// TI - Glucolipotoxicity, beta cells, and diabetes: the emperor has no clothes JO - Diabetes VL - 69 ID - Weir2019 ER -