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Table 3 Hazard ratios of metabolic syndrome across tertiles of nut consumption according to transcription factor-7-like 2 rs7903146 and rs12255372 genotypes

From: TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study

  Tertiles of nut consumption
T1 T2 T3 Ptrenda
Rs7903146
CC
 Model 1 1 0.95 (0.63–1.42) 0.97 (0.65–1.45) 0.97
 Model 2 1 0.88 (0.58–1.33) 0.84 (0.55–1.27) 0.71
 Model 3 1 0.85 (0.56–1.29) 0.82 (0.54–1.25) 0.63
CT
 Model 1 1 0.71 (0.51–0.99) 0.64 (0.45–0.90) 0.02
 Model 2 1 0.67 (0.47–0.94) 0.61 (0.43–0.87) 0.01
 Model 3 1 0.70 (0.49–0.99) 0.63 (0.44–0.90) 0.02
TT
 Model 1 1 0.80 (0.46–1.39) 0.61 (0.34–1.11) 0.27
 Model 2 1 0.79 (0.44–1.41) 0.64 (0.35–1.18) 0.36
 Model 3 1 0.78 (0.43–1.42) 0.72 (0.39–1.34) 0.56
CT + TT
 Model 1 1 0.73 (0.55–0.97) 0.67 (0.50–0.90) 0.01
 Model 2 1 0.70 (0.52–0.93) 0.66 (0.49–0.89) 0.01
 Model 3 1 0.72 (0.54–0.97) 0.67 (0.50–0.91) 0.02
Rs12255372
GG
 Model 1 1 0.94 (0.64–1.38) 1.04 (0.71–1.52) 0.86
 Model 2 1 0.83 (0.55–1.24) 0.89 (0.60–1.32) 0.65
 Model 3 1 0.80 (0.53–1.19) 0.92 (0.62–1.37) 0.54
GT
 Model 1 1 0.78 (0.56–1.10) 0.77 (0.55–1.08) 0.18
 Model 2 1 0.74 (0.52–1.04) 0.68 (0.48–0.96) 0.04
 Model 3 1 0.75 (0.53–1.07) 0.67 (0.47–0.95) 0.03
TT
 Model 1 1 0.53 (0.29–0.98) 0.49 (0.26–0.91) 0.03
 Model 2 1 0.58 (0.31–1.09) 0.63 (0.32–1.26) 0.18
 Model 3 1 0.66 (0.34–1.26) 0.70 (0.35–1.39) 0.39
GT + TT  
 Model 1 1 0.69 (0.51–0.93) 0.69 (0.51–0.93) 0.03
 Model 2 1 0.68 (0.51–0.92) 0.66 (0.49–0.90) 0.02
 Model 3 1 0.69 (0.51–0.93) 0.66 (0.49–0.69) 0.01
  1. Model 1 was crude
  2. Model 2 was adjusted for age, gender, smoking, physical activity, education levels, occupational status, total energy intake, fiber intake, family history of diabetes, family history of cardiovascular disease
  3. Model 3 was additionally adjusted for BMI at baseline
  4. aThe median intake of each tertile category was assigned and then these quartile median variables were included as a continuous variable in cox proportional hazards regression