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Table 3 Hazard ratios of metabolic syndrome across tertiles of nut consumption according to transcription factor-7-like 2 rs7903146 and rs12255372 genotypes

From: TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study

 

Tertiles of nut consumption

T1

T2

T3

Ptrenda

Rs7903146

CC

 Model 1

1

0.95 (0.63–1.42)

0.97 (0.65–1.45)

0.97

 Model 2

1

0.88 (0.58–1.33)

0.84 (0.55–1.27)

0.71

 Model 3

1

0.85 (0.56–1.29)

0.82 (0.54–1.25)

0.63

CT

 Model 1

1

0.71 (0.51–0.99)

0.64 (0.45–0.90)

0.02

 Model 2

1

0.67 (0.47–0.94)

0.61 (0.43–0.87)

0.01

 Model 3

1

0.70 (0.49–0.99)

0.63 (0.44–0.90)

0.02

TT

 Model 1

1

0.80 (0.46–1.39)

0.61 (0.34–1.11)

0.27

 Model 2

1

0.79 (0.44–1.41)

0.64 (0.35–1.18)

0.36

 Model 3

1

0.78 (0.43–1.42)

0.72 (0.39–1.34)

0.56

CT + TT

 Model 1

1

0.73 (0.55–0.97)

0.67 (0.50–0.90)

0.01

 Model 2

1

0.70 (0.52–0.93)

0.66 (0.49–0.89)

0.01

 Model 3

1

0.72 (0.54–0.97)

0.67 (0.50–0.91)

0.02

Rs12255372

GG

 Model 1

1

0.94 (0.64–1.38)

1.04 (0.71–1.52)

0.86

 Model 2

1

0.83 (0.55–1.24)

0.89 (0.60–1.32)

0.65

 Model 3

1

0.80 (0.53–1.19)

0.92 (0.62–1.37)

0.54

GT

 Model 1

1

0.78 (0.56–1.10)

0.77 (0.55–1.08)

0.18

 Model 2

1

0.74 (0.52–1.04)

0.68 (0.48–0.96)

0.04

 Model 3

1

0.75 (0.53–1.07)

0.67 (0.47–0.95)

0.03

TT

 Model 1

1

0.53 (0.29–0.98)

0.49 (0.26–0.91)

0.03

 Model 2

1

0.58 (0.31–1.09)

0.63 (0.32–1.26)

0.18

 Model 3

1

0.66 (0.34–1.26)

0.70 (0.35–1.39)

0.39

GT + TT

 

 Model 1

1

0.69 (0.51–0.93)

0.69 (0.51–0.93)

0.03

 Model 2

1

0.68 (0.51–0.92)

0.66 (0.49–0.90)

0.02

 Model 3

1

0.69 (0.51–0.93)

0.66 (0.49–0.69)

0.01

  1. Model 1 was crude
  2. Model 2 was adjusted for age, gender, smoking, physical activity, education levels, occupational status, total energy intake, fiber intake, family history of diabetes, family history of cardiovascular disease
  3. Model 3 was additionally adjusted for BMI at baseline
  4. aThe median intake of each tertile category was assigned and then these quartile median variables were included as a continuous variable in cox proportional hazards regression