A nonlinear association of total cholesterol with all-cause and cause-specific mortality

Nutrition & Metabolism

Table 3 The results of two-piecewise linear regression model between total cholesterol and cause-specific mortality

	All-cause mortality	Cardiovascular mortality	Cancer mortality
	HR (95% CI) p value	HR (95% CI) p value	HR (95% CI) p value
Cutoff value, mg/dL	172(4.45 mmol/L)	267(6.90 mmol/L)	205(5.30 mmol/L)
< Cut-off value	0.60 (0.52, 0.70) < 0.0001	0.99 (0.89, 1.10) 0.8479	0.79 (0.67, 0.93) 0.0058
≥ Cut-off value	1.01 (0.96, 1.06) 0.8160	1.38 (1.09, 1.75) 0.0084	1.05 (0.92, 1.21) 0.4612
P for log likelihood ratio test	< 0.001	0.053	0.032

HR, hazard ratio; CI, confidence interval
The two-piecewise linear regression model were adjusted for age, gender, race, education level, married, smoking, body mass index, systolic blood pressure, estimated glomerular filtration rate, high density lipoprotein cholesterol, energy intake, comorbidities (hypertension, and diabetes), and medication use (antihypertensive drugs, hypoglycemic agents, and lipid-lowering drugs)

ISSN: 1743-7075