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Table 2 Risks of developing NAFLD in relation to FM/FFM ratio by sex and obesity status

From: Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

p for trend

Per 1 SD increment

p value

Men (n = 1017)

 Non-obesity (n = 612)

  Model 1

Reference

1.32 (0.65–2.71)

1.47 (0.73–2.98)

3.17 (1.66–6.04)

< 0.001

1.59 (1.28–1.98)

< 0.001

  Model 2

1.19 (0.57–2.48)

1.24 (0.60–2.57)

2.80 (1.44–5.42)

0.001

1.55 (1.23–1.95)

< 0.001

  Model 3

0.89 (0.42–1.91)

0.92 (0.43–1.97)

1.61 (0.79–3.28)

0.127

1.27 (0.99–1.63)

0.064

 Obesity (n = 405)

  Model 1

Reference

1.35 (0.73–2.50)

1.66 (0.90–3.04)

2.65 (1.46–4.81)

0.001

1.37 (1.12–1.69)

0.003

  Model 2

1.40 (0.74–2.64)

1.51 (0.81–2.83)

2.52 (1.35–4.71)

0.004

1.33 (1.08–1.65)

0.009

  Model 3

1.23 (0.64–2.39)

1.23 (0.64–2.38)

2.15 (1.11–4.18)

0.028

1.25 (0.99–1.58)

0.064

Women (n = 2402)

 Non-obesity (n = 1569)

  Model 1

Reference

1.47 (0.91–2.39)

2.06 (1.30–3.26)

3.08 (1.98–4.78)

< 0.001

1.44 (1.24–1.66)

< 0.001

  Model 2

1.57 (0.96–2.57)

2.21 (1.38–3.54)

3.27 (2.07–5.16)

< 0.001

1.44 (1.24–1.67)

< 0.001

  Model 3

1.29 (0.78–2.16)

1.77 (1.08–2.91)

2.35 (1.44–3.81)

< 0.001

1.28 (1.10–1.50)

0.002

 Obesity (n = 833)

  Model 1

Reference

1.12 (0.74–1.72)

1.25 (0.82–1.90)

1.72 (1.14–2.59)

0.009

1.24 (1.08–1.44)

0.003

  Model 2

1.20 (0.78–1.85)

1.29 (0.84–1.99)

1.93 (1.27–2.94)

0.002

1.29 (1.12–1.50)

0.001

  Model 3

1.14 (0.73–1.79)

1.13 (0.72–1.79)

1.63 (1.05–2.55)

0.039

1.22 (1.04–1.42)

0.013

  1. Data are odds ratio (OR) and 95% confidence interval (CI)
  2. P values were calculated from the logistic regression models. Model 1 was crude model. Model 2 adjusted for age, current smoking, current drinking, active physical activity, and education level. Model 3 further adjusted for fasting glucose, HOMA-IR, triglycerides, LDL-C, HDL-C, white blood cells based on model 2
  3. FM/FFM fat-to-fat free mass ratio, OR odds ratio, CI confidence interval, SD standard deviation, HOMA-IR homeostasis model assessment of insulin resistance, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol