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Table 1 The summery of potentiating and preventing role of lncRNAs in fatty liver disease

From: A comprehensive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease

lncRNA Target Role in NAFLD, NASH, and fibrosis Expression in disease References
SRA FoxO1
PPARγ
Promotes adipocytes differentiation
Promotes insulin-stimulated glucose absorption
Prevents FFA oxidation
Upregulated [36, 37, 39]
NEAT1 miR-146-5p
ROCK1
Promotes adipogenesis, lipogenesis, and lipid absorption Upregulated [40, 42, 43, 45]
MALAT1 CXCL5 Contributes to the hepatic insulin resistance Upregulated [54]
UC372 miR-195/miR-4668
RALGAPA1
Initiates hepatic steatosis Upregulated [56, 142]
lncARSR YAP1 Modulates cholesterol metabolism Upregulated [61]
APOA4-AS HuR protein Enhances insulin and triglyceride secretion
Inhibits gluconeogenesis
Upregulated [66, 67]
lnc-H19 hnRNP1
PPARγ
Facilitates lipid accumulation in hepatocytes
Enhances hepatic steatosis development
Upregulated [69, 74, 76]
NONMMUT010685 NONMMUT050689 XBP1
RIPK1
Progresses NASH development Upregulated [79]
RUNX1 CCL2
PIK3CA
Increases inflammation in liver Upregulated [88,89,90]
HOTAIR miR-29b
PTEN
Accelerates liver fibrosis and carcinogenesis Upregulated [95, 143]
Gm15622 miR-742-3p Increases lipid accumulation in liver Upregulated [96]
HULC MAPK Promotes NAFLD development Upregulated [99, 100]
lnc18q22.2 BCL2 family Decreases cell viability in hepatic cell lines Upregulated [103]
lncLSTR Cyp8b1
FXR
Enhances TG clearance Downregulated [104]
Mirt2 miR-34a-5p Impedes insulin resistance and hepatic steatosis
Modulates gluconeogenesis/lipogenesis in hepatocytes
Downregulated [109, 115]
MEG3 LRP6
miR-136
Nrf-2
miR-140-5p
Inhibits lipid generation and secretion
Promotes osteogenesis despite adipogenesis
Downregulated [117, 120, 122]
FLRL2 Arntl Alleviates NAFLD and steatosis
Decrease ER stress and liver inflammation
Downregulated [123]
lncSHGL hnRNPA1
Calmodulin
Suppresses gluconeogenesis
Attenuates hyperglycemia and fatty liver
Downregulated [125]
lncHR1 FAS
SREBP-1c
Inhibits the accumulation of fatty acids and TG Downregulated [128, 129]
MRAK052686 ZBTB20 Regulates cellular stress Downregulated [132, 133, 135]