Table 1 The summery of potentiating and preventing role of lncRNAs in fatty liver disease
lncRNA | Target | Role in NAFLD, NASH, and fibrosis | Expression in disease | References |
|---|---|---|---|---|
SRA | FoxO1 PPARγ | Promotes adipocytes differentiation Promotes insulin-stimulated glucose absorption Prevents FFA oxidation | Upregulated | |
NEAT1 | miR-146-5p ROCK1 | Promotes adipogenesis, lipogenesis, and lipid absorption | Upregulated | |
MALAT1 | CXCL5 | Contributes to the hepatic insulin resistance | Upregulated | [54] |
UC372 | miR-195/miR-4668 RALGAPA1 | Initiates hepatic steatosis | Upregulated | |
lncARSR | YAP1 | Modulates cholesterol metabolism | Upregulated | [61] |
APOA4-AS | HuR protein | Enhances insulin and triglyceride secretion Inhibits gluconeogenesis | Upregulated | |
lnc-H19 | hnRNP1 PPARγ | Facilitates lipid accumulation in hepatocytes Enhances hepatic steatosis development | Upregulated | |
NONMMUT010685 NONMMUT050689 | XBP1 RIPK1 | Progresses NASH development | Upregulated | [79] |
RUNX1 | CCL2 PIK3CA | Increases inflammation in liver | Upregulated | |
HOTAIR | miR-29b PTEN | Accelerates liver fibrosis and carcinogenesis | Upregulated | |
Gm15622 | miR-742-3p | Increases lipid accumulation in liver | Upregulated | [96] |
HULC | MAPK | Promotes NAFLD development | Upregulated | |
lnc18q22.2 | BCL2 family | Decreases cell viability in hepatic cell lines | Upregulated | [103] |
lncLSTR | Cyp8b1 FXR | Enhances TG clearance | Downregulated | [104] |
Mirt2 | miR-34a-5p | Impedes insulin resistance and hepatic steatosis Modulates gluconeogenesis/lipogenesis in hepatocytes | Downregulated | |
MEG3 | LRP6 miR-136 Nrf-2 miR-140-5p | Inhibits lipid generation and secretion Promotes osteogenesis despite adipogenesis | Downregulated | |
FLRL2 | Arntl | Alleviates NAFLD and steatosis Decrease ER stress and liver inflammation | Downregulated | [123] |
lncSHGL | hnRNPA1 Calmodulin | Suppresses gluconeogenesis Attenuates hyperglycemia and fatty liver | Downregulated | [125] |
lncHR1 | FAS SREBP-1c | Inhibits the accumulation of fatty acids and TG | Downregulated | |
MRAK052686 | ZBTB20 | Regulates cellular stress | Downregulated |