Fig. 1

SIRT1 deficiency abrogates the effect of BP in AFLD hepatocyte ultrastructure. A Hepatocyte ultrastructure in mice of different groups (Scale bar: 10 μm). The arrow indicates mitochondria; B Hepatic necrosis area and mitochondrial swelling. CG, control group; MG, AFLD model group; SI, AFLD mice treated with SIRT1 siRNA; BJ, AFLD mice treated with blueberry; BJSI, AFLD mice treated with blueberry and SIRT1 siRNA; BJB, AFLD mice treated with BP; BJBSI, AFLD mice with BP and SIRT1 siRNA. Different lowercase letters (a, b, c, and d) represent significant differences (*P < 0.05, Student’s t-test, n = 8)