Impact of mixed meal tolerance test composition on measures of beta-cell function in type 2 diabetes

Nutrition & Metabolism

Table 2 Intra-and inter-individual variation of parameters of glucose metabolism during two different MMTTs

Variables	MMTT-comparison of one meal three times				MMTT-comparison of two different meals
Variables	iAUC	CV Intra-individual variation (%)	CV Inter-individual variation (%)	ICC	iAUC	CV Intra-individual variation (%)	CV Inter-individual variation (%)	ICC
C-peptide	672 (276; 1269)	18.2 (2.6; 40.3)	74.2	0.69	759 (377; 1339)	16.9 (0.6; 77.9)	42.7 (41.6; 43.9)	0.51
Insulin	5456^† (2363; 9281)	19.7^† (2.2; 52.4)	70.5^†	0.70	7082^§ (2473; 17,080)	20.5^§ (5.2; 61.8)	69.0^§ (64.6; 73.4)	0.59
Glucose	4435 (− 1706; 12,671)	18.9 (− 80.7; 74.9)	207.7	0.89	5276 (810; 15,270)	45.9 (6.9; 97.2)	69.1 (66.6; 71.6)	0.53

Data are means, coefficient of variation (CV), minimum and maximum and intraclass correlation coefficient (ICC). Data are given in ng*ml⁻¹ *3 h⁻¹ for iAUC C-peptide, mU*l⁻¹*3 h⁻¹for iAUC insulin, mg*dl⁻¹*3 h⁻¹ for iAUC glucose
Data are available for ^§n = 17 out of 20 measurements or ^†n = 27 out of 30 measurements
iAUC, incremental area under the curve; CV, coefficient of variation; ICC, intraclass correlation coefficient; MMTT, mixed meal tolerance test

ISSN: 1743-7075