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Table 1 Pathologies associated with altered cellular metabolism and satellite cell dysfunction

From: Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook



Metabolic disturbance(s)


Tamilarasan et al. [11]

MCK(m)-hLPL mice

Striated muscle targeted elevation of lipids

Reduced muscle weight and cross-sectional area (or regeneration) after injury

Tamilarasan et al. [11]

hLPL transfected C2C12 myoblasts

Elevated intracellular FFA

Impaired myoblasts fusion and myogenesis

Fu et al. [86]

High-fat diet fed mice


Reduced muscle regeneration and reduced primary satellite cell pool

D’Souza et al. [25]

C57BL/6-Ins2Akita/J mice

Type I diabetes

Reduced muscle weight

Reduced satellite cell activation and proliferation

Reduced myogenic transcripts

Xu et al. [26]

16 week High-Fat Diet fed mice


Impaired primary satellite cell differentiation

García-Prat et al. [36]

GFP–LC3 Geriatric mice

Advanced age/Senescence

Impaired satellite cell autophagy

Impaired expansion and fusion of transplanted myoblasts

García-Prat et al. [36]

Human primary myoblasts

Advanced age/Senescence

Impaired clearance of cellular components and increased ROS

Reduction in proliferation

Servián-Morilla et al. [37]

Limb-girdle muscular dystrophy 2H patients

Premature senescence

Fatty replacement of muscle

Reduced myoblast proliferation and differentiation

Increased autophagic flux in myoblast

Kudryashova et al. [38]

Trim32–/– (Limb-girdle dystrophy) mice

Premature senescence

Myoblast growth arrest

Impaired myoblasts self-renewal and differentiation

Yablonka-Reuveni et al

Bell et al

mdx mice

Mitochondrial abnormalities [47]

Accelerated muscle regeneration [42]

Schaaf et al. [48]

Pompe patients

(4 disease groups)

Lysosomal glycogen accumulation

Impaired satellite cell activation and differentiation

Lagalice et al. [49]

GAA-KO 6neo/6neo (Pompe) mice

Lysosomal glycogen accumulation

Lipid accumulation

Impaired muscle regeneration

Increase satellite cell activation (and quantity for young mice only)

Schaaf et al. [50]

Gaa−/− (Pompe) mice

Lysosomal glycogen accumulation

Increased satellite cell pool

Impaired muscle regeneration

Manzano et al. [55]

SOD1-G93A mutant (ALS) mice

Altered superoxide dismutase function

Alterations in satellite cell abundance and activation

Gouzi et al. [8]

COPD patients

Elevated ROS

Increased myoblast autophagy

Pomiès et al. [63]

COPD patients

Increased oxidative stress

Myoblasts with: greater susceptibility to oxidative stress, reduced fusion capacity, increased protein carbonylation

Myotubes with reduced diameter

Rocheteau et al. [64]

Cecal ligation and puncture in mice


Impaired satellite cell proliferation

Reduced satellite cell quantity

Impaired muscle regeneration

Altered satellite cell mitochondria