Table 1 Pathologies associated with altered cellular metabolism and satellite cell dysfunction
Investigators | Model | Metabolic disturbance(s) | Outcome |
|---|---|---|---|
Tamilarasan et al. [11] | MCK(m)-hLPL mice | Striated muscle targeted elevation of lipids | Reduced muscle weight and cross-sectional area (or regeneration) after injury |
Tamilarasan et al. [11] | hLPL transfected C2C12 myoblasts | Elevated intracellular FFA | Impaired myoblasts fusion and myogenesis |
Fu et al. [86] | High-fat diet fed mice | Obesity | Reduced muscle regeneration and reduced primary satellite cell pool |
D’Souza et al. [25] | C57BL/6-Ins2Akita/J mice | Type I diabetes | Reduced muscle weight Reduced satellite cell activation and proliferation Reduced myogenic transcripts |
Xu et al. [26] | 16Â week High-Fat Diet fed mice | Pre-diabetes/Obesity | Impaired primary satellite cell differentiation |
GarcÃa-Prat et al. [36] | GFP–LC3 Geriatric mice | Advanced age/Senescence | Impaired satellite cell autophagy Impaired expansion and fusion of transplanted myoblasts |
GarcÃa-Prat et al. [36] | Human primary myoblasts | Advanced age/Senescence | Impaired clearance of cellular components and increased ROS Reduction in proliferation |
Servián-Morilla et al. [37] | Limb-girdle muscular dystrophy 2H patients | Premature senescence Fatty replacement of muscle | Reduced myoblast proliferation and differentiation Increased autophagic flux in myoblast |
Kudryashova et al. [38] | Trim32–/– (Limb-girdle dystrophy) mice | Premature senescence | Myoblast growth arrest Impaired myoblasts self-renewal and differentiation |
Yablonka-Reuveni et al Bell et al | mdx mice | Mitochondrial abnormalities [47] | Accelerated muscle regeneration [42] |
Schaaf et al. [48] | Pompe patients (4 disease groups) | Lysosomal glycogen accumulation | Impaired satellite cell activation and differentiation |
Lagalice et al. [49] | GAA-KO 6neo/6neo (Pompe) mice | Lysosomal glycogen accumulation Lipid accumulation | Impaired muscle regeneration Increase satellite cell activation (and quantity for young mice only) |
Schaaf et al. [50] | Gaa−/− (Pompe) mice | Lysosomal glycogen accumulation | Increased satellite cell pool Impaired muscle regeneration |
Manzano et al. [55] | SOD1-G93A mutant (ALS) mice | Altered superoxide dismutase function | Alterations in satellite cell abundance and activation |
Gouzi et al. [8] | COPD patients | Elevated ROS | Increased myoblast autophagy |
Pomiès et al. [63] | COPD patients | Increased oxidative stress | Myoblasts with: greater susceptibility to oxidative stress, reduced fusion capacity, increased protein carbonylation Myotubes with reduced diameter |
Rocheteau et al. [64] | Cecal ligation and puncture in mice | Sepsis | Impaired satellite cell proliferation Reduced satellite cell quantity Impaired muscle regeneration Altered satellite cell mitochondria |