Fig. 3

Schematic representation of STAT3 isoforms domains. STAT3 structure is composed by a helical N-terminus domain (NTD); a coiled-coil domain (CCD); a central DNA-binding domain (DBD); a linker domain (LD); an Src homology 2 (SH2) domain; and a C-terminal transactivation domain (TAD) with a conserved tyrosine residue at 705 (Y705) and a serine phosphorylation site at 727(S727)