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Table 1 STAT3 isoforms

From: STAT3 phosphorylation in central leptin resistance

STAT3 isoform Molecular weight (kDa) Structure Function References
STAT3α 92 Full length Typical STAT3 function [47]
STAT3β 83 C-terminal truncated form (missing Ser727) Greater DNA binding activity; Distinct regulatory and transcriptional functions; Suppressive effect on STAT3 [51]
STAT3γ 72 C-terminal truncated form (missing Ser727and Tyr705) Activated in the terminal stage of granulocytic differentiation [48]
STAT3δ 64 C-terminal truncated form (missing Ser727 and Tyr705) Activated in the early stage of granulocytic differentiation [48]