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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Protective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats

Fig. 2

Effects of CR on metabolic indices. The diabetic Sprague–Dawley rats model was induced by feeding HFD for 8 weeks, followed by a single STZ injection (30 mg/kg). The rats were either provided HFD ab libitum (HFD + AL + STZ group) or fed HFD with a 30% restriction regimen (HFD + CR + STZ group). Rats given free access to normal chow diet served as a blank control (ND + AL group). All interventions lasted for 20 weeks. a, b body mass; c, d water intake; e, f RBG; g, h FBG; i IPGTT; j AUC of IPGTT; k FFAs. Data were presented as the mean ± standard deviation (SD). For a–h, n = 10–20 for the ND + AL group and n = 6–14 for the other two groups. Six rats from each group were randomly chosen for the IPGTT experiment and lipid profile detection. *p < 0.05 between the two groups; CR, calorie restriction; HFD, high-fat diet; STZ, streptozotocin; RBG, random blood glucose; FBG, fasting blood glucose; IPGTT, intraperitoneal glucose tolerance test; AUC, area under curve; FFAs, free fat acids; ND + AL, normal diet provided ad libitum (BCT group); HFD + AL + STZ, HFD provided ad libitum and STZ injection (MCT group); HFD + CR + STZ, HFD with 30% CR and STZ injection (CR group)

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