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Table 6 Relative mRNA expression of Notch1 Hes1, claudin2, and ZO-1 in colon tissue (\(\overline{x }\) ± s, n = 6)

From: Combined effect of vitamin C and vitamin D3 on intestinal epithelial barrier by regulating Notch signaling pathway

Group

Notch-1

Hes1

Claudin-2

ZO-1

Control

1.46 ± 1.27

1.17 ± 0.83

2.74 ± 2.26

1.11 ± 0.60

LVC + VD3 + DSS

318.88 ± 202.43a

9.68 ± 6.94a

1.26 ± 1.69

5.38 ± 3.27

MVC + VD3 + DSS

3.29 ± 3.11

0.53 ± 0.22b

1.49 ± 0.40

6.42 ± 1.21

HVC + VD3 + DSS

1.12 ± 1.53b

0.34 ± 0.11b

1.25 ± 1.24

8.71 ± 4.90a

P value

0.011

0.030

0.619

0.077

  1. aP indicates compared with the control group, P < 0.05; b P expression is compared with the LVC + VD3 group, P < 0.05.