Fig. 3

Effect of PS-341 on TM4 protein and metabolic homeostasis. a, b The effect of PS-341 on TM4 expression in HUVECs. c PS-341 retards TM4 degradation in HUVEC. d Blood glucose of db/db mice treated with PS-341. e SBP of db/db mice treated with PS-341. f DBP of db/db mice treated with PS-341. g Fasting insulin of db/db mice treated with PS-341. h Oral glucose tolerance test. i Glucose infusion rate after glucose homeostasis