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Fig. 1 | Nutrition & Metabolism

Fig. 1

From: The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphagia and obesity

Fig. 1

The c-Fos expression in the brain after refeeding and distribution of GLP-1R in the DMH. A–F: The representative images of c-Fos expression in the SCN (A, D), DMH (B, E) and NTS (C, F) after fasting (A–C) or refeeding (D–F) rats. Refeeding was performed for 2 h after 16 h of fasting in normal 12 h light/12 h dark conditions. Scale bar = 100 μm. G: The number of c-Fos per sections in feeding-related brain regions. (n = 4 each). ARC: arcuate nucleus, Amy: amygdala, BNST: bed nucleus of stria terminalis, DMH: dorsomedial hypothalamic nucleus, DR: dorsal raphe, LC: locus coeruleus, NTS: nucleus tractus solitarius, SCN: suprachiasmatic nucleus, SON: supraoptic nucleus, SuM: supramammillary nucleus, POA: preoptic area, PVN: paraventricular hypothalamic nucleus, VMH: ventromedial hypothalamic nucleus. H–J DAPI nuclear staining (H) and GLP-1R immunostaining (I) in the DMH and a merged image of H and I (J). Scale bars = 100 μm. Each image located in the upper left corner of H–J is an enlarged image of the dashed square. Scale bars = 10 μm

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Nutrition & Metabolism

ISSN: 1743-7075

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