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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway

Fig. 2

a On day 14, the serum uric level was significantly higher than that of the control group (P < 0.05). On day 21, the 1 mg/kg (P < 0.05) and 5 mg/kg (P < 0.001) EB groups exhibited urate-lowering effects. On day 28, there was no obvious urate-lowering effect of EB. b The creatinine level of the HUA group was not significantly higher than that of the control group. On day 21, the creatinine level of the mice in the hyperuricemia group was higher (P < 0.05). c In the OVX group, a significant drop in estradiol levels was observed on day 14 (P < 0.0001) and day 21 (P < 0.0001). In the OVX + EB intervention group, the level of estradiol also decreased significantly on day 14 (P < 0.0001) and day 21 (P < 0.0001). d A significant increase in the serum urate level in the OVX group (P < 0.05) and a urate-lowering effect of EB (OVX + EB vs. OVX, P < 0.05) could be observed on day 21

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