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Table 3 Adjusted ORs and 95% CIs across the quartiles of baseline SUA and SUA changes for incident MetS in major subgroups

From: Association between baseline and changes in serum uric acid and incident metabolic syndrome: a nation-wide cohort study and updated meta-analysis

Subgroups

N

Quartiles of baseline SUA†

P for interaction*

Quartiles of absolute changes in SUA during follow-up†

P for interaction*

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Sex

     

0.767

    

0.432

Men

1783

Reference

1.09 (0.66–1.81)

1.20 (0.74–1.97)

1.53 (0.92–2.54)

 

Reference

1.17 (0.68–2.01)

1.76 (1.05–2.95)

2.06 (1.27–3.33)

 

Women

1996

Reference

1.09 (0.70–1.71)

1.43 (0.93–2.20)

1.58 (1.02–2.45)

 

Reference

1.34 (0.88–2.03)

1.23 (0.81–1.91)

1.87 (1.22–2.85)

 

Age groups

     

0.469

    

0.465

45–59 years

1945

Reference

0.96 (0.61–1.51)

1.58 (1.02–2.45)

1.65 (1.04–2.62)

 

Reference

0.95 (0.59–1.53)

1.27 (0.81–2.01)

1.65 (1.06–2.56)

 

 ≥ 60 years

1834

Reference

1.24 (0.76–2.04)

1.15 (0.70–1.88)

1.47 (0.91–2.39)

 

Reference

1.63 (1.03–2.58)

1.46 (0.91–2.36)

2.15 (1.36–3.37)

 

BMI groups

     

0.617

    

0.671

 < 24 kg/m2

2628

Reference

0.94 (0.57–1.56)

1.21 (0.75–1.95)

1.58 (0.97–2.57)

 

Reference

0.99 (0.61–1.63)

1.39 (0.87–2.23)

1.85 (1.17–2.91)

 

 ≥ 24 kg/m2

1151

Reference

1.14 (0.72–1.81)

1.28 (0.81–2.01)

1.51 (0.95–2.37)

 

Reference

1.59 (1.01–2.51)

1.45 (0.91–2.32)

1.86 (1.21–2.91)

 
  1. BMI, body mass index; BP, blood pressure; CI, confidence interval; eGFR, estimated glomerular filtration rate; FBG, fasting blood glucose; HDL-C, high-density lipoprotein cholesterol; Mets, metabolic syndrome; OR, odd ratio; SUA, serum uric acid; TG, triglycerides; WC, waist circumference
  2. †Adjusted for baseline age (continuous, years), gender (men and women), residence (urban and rural), education level (illiterate, primary school, middle school or above), marital status (married and unmarried), cigarette smoking (never, former, and current), alcohol drinking (never, former, and current), WC (continuous, cm), BMI (continuous, kg/m2), systolic BP (continuous, mmHg), FBG (continuous, mg/dL), TG (continuous, mg/dL), and HDL-C (continuous, mg/dL), and eGFR (continuous, mL/min/1.73 m2). Baseline SUA (continuous, mg/dL) was additionally adjusted as covariate in the analysis of quartiles of absolute changes in SUA
  3. *P values for interaction were estimated using the Wald test for the product term of the stratifying variable and SUA groups to the main model
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Nutrition & Metabolism

ISSN: 1743-7075

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