Table 3 Odds ratios of incident hyperuricemia associated with changes in weight and waist circumference in middle-aged and older Chinese population

Weight change, kg

 Loss of ≥ 4

322

21 (6.52)

0.56 (0.35–0.91)

0.50 (0.31–0.82)

0.44 (0.26–0.74)

 Loss of ≥ 2 to loss of < 4

412

33 (8.01)

0.71 (0.48–1.06)

0.67 (0.45–1.00)

0.63 (0.41–0.98)

 Loss of < 2 to gain of ≤ 2

1364

146 (10.70)

1.00

1.00

1.00

 Gain of > 2 to gain of ≤ 4

415

43 (10.36)

1.00 (0.69–1.43)

0.98 (0.68–1.41)

0.96 (0.64–1.43)

 Gain of > 4

382

50 (13.09)

1.34 (0.95–1.90)

1.39 (0.98–1.97)

1.62 (1.10–2.37)

 P for trend

0.001

 < 0.001

 < 0.001

Weight change, per SD increase (4.25 kg)

2895

293 (10.12)

1.24 (1.11–1.39)

1.27 (1.13–1.42)

1.37 (1.21–1.55)

Waist circumference change, cm

 Loss of ≥ 6

361

23 (6.37)

0.51 (0.32–0.81)

0.51 (0.32–0.80)

0.45 (0.27–0.73)

 Loss of ≥ 3 to loss of < 6

315

28 (8.89)

0.73 (0.48–1.12)

0.73 (0.47–1.12)

0.65 (0.41–1.04)

 Loss of < 3 to gain of ≤ 3

1219

141 (11.57)

1.00

1.00

1.00

 Gain of > 3 to gain of ≤ 6

501

38 (7.58)

0.65 (0.45–0.95)

0.65 (0.45–0.95)

0.66 (0.44–1.03)

 Gain of > 6

499

63 (12.63)

1.15 (0.83–1.58)

1.19 (0.86–1.64)

1.24 (0.87–1.76)

 P for trend

0.011

0.007

0.001

Waist circumference change, per SD increase (6.14 cm)

2895

293 (10.12)

1.20 (1.06–1.36)

1.21 (1.07–1.38)

1.27 (1.11–1.46)