Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity

Table 2 Indicators of cell injury and metabolism in hepatocytes

Parameters	Control	Etomoxir	Etomoxir + carnitine	p values
ALT (U/L)	3.35 ± 0.98	8.16 ± 0.90	5.06 ± 1.36	P^a < 0.01, P^b < 0.05
AST (U/L)	5.23 ± 0.54	10.50 ± 1.28	7.15 ± 1.36	P^a < 0.01, P^b < 0.05
LDH (U/L)	16.36 ± 2.78	33.53 ± 3.02	20.21 ± 5.82	P^a < 0.01, P^b < 0.05
TG (mmol/mL)	0.25 ± 0.02	0.51 ± 0.04	0.21 ± 0.01	P^a < 0.0001, P^b < 0.0001
OCT (ng/mL)	49.40 ± 8.73	109.06 ± 10.32	78.82 ± 8.59	P^a < 0.01, P^b < 0.05
b-HB (mmol/L)	93.22 ± 5.84	43.62 ± 9.71	73.40 ± 8.54	P^a < 0.01, P^b < 0.01

HepG2 cells were treated with or without 0.1 mM etomoxir or with 0.1 mM etomoxir + 0.2 mM carnitine for 24 h. After treatment, ALT, AST, LDH, TG, OCT, and β-HB levels in the culture medium were evaluated using an auto-analyzer. Student’s t-test was used to calculate the P values
^aEtomoxir versus control
^bEtomoxir + carnitine versus etomoxir

ISSN: 1743-7075