Ability of dietary factors to affect homocysteine levels in mice: a review

Nutrition & Metabolism

Table 1 Plasma homocysteine levels in mice fed AIN-93-based control diets

Mouse strain	Sex	Age at baseline	Duration (weeks)	Plasma Hcy (µmol/l)	n	References
129/Sv	f + m	3 wks	6	0.1^#	15	[9]
129/Sv	f + m	3 wks	9	0.1^#	15	[9]
129/Sv	f + m	3 wks	9–13	2.0 ± 0.6^b	nda	[10]
CD-1	f + m	Adult	9	2.5^#	13	[11]
C57BL/6	m	6 wks	8	2.5 ± 0.7^b	nda	[12]
C57BL/6	m	6 wks	4	2.6 ± 0.8^b	nda	[12]
129/Sv	f + m	3 wks	9	2.8 ± 0.3^nda	nda	[13]
Swiss	m	3 wks	27	3.0 ± 0.4^b	6–8	[14]
C57BL/6	m	3 wks	5	3.0 ± 2.2^c	nda	[15]
C57BL/6	m	6 wks	8	3.3 ± 0.8^b	6	[16]
C57BL/6	f	8 wks	9	3.6 ± 0.7^b	15	[17]
SAMP8	m	13 wks	4	4.0^#	nda	[18]
BALB/c	f	17 wks	2	5.2 ± 0.2^b	23	[19]
Swiss	m	3 wks	10	5.2 ± 0.6^b	6–8	[14]
C57BL/6	f	3 wks	5	5.4 ± 1.7^c	nda	[15]
C57BL/6	f	6–8 wks	7	5.5 ± 5.4^c	10	[15]
SAMP8	m	17 wks	26	6.5^#	15	[18]
SAMR1	m	17 wks	26	6.5^#	nda	[18]
Swiss	f	3 wks	10	7.1 ± 0.7^b	6–8	[14]
Swiss	f	3 wks	27	8.1 ± 0.8^b	6–8	[14]
Swiss	m	3 wks	1	8.7 ± 0.9^b	6–8	[14]
Swiss	f	Adult	3	9.2^#	6–8	[14]
Swiss	f	3 wks	1	9.7 ± 0.6^b	6–8	[14]
C57BL/6	f	7 wks	2	16.7 ± 1.5^a	20	[20]
BALB/c	m	17 wks	52	18^#	nda	[19]
BALB/c	f	17 wks	52	22.5^#	nda	[19]

f, female; m, male; n, number of included mice; nda, no data available; wks, weeks
^aMean ± standard deviation
^bMean ± standard error
^cMedian ± interquartile range
^#Read from diagrams of data from mice that received AIN-93-based control diets containing 25 µg vitamin B₁₂, 7 mg vitamin B₆, 2 mg folate, 3 g methionine + cystine and 2.5 g choline per kg diet; only studies with complete data sets about mouse strain, sex, age at baseline, and the duration of feeding (in weeks) were included

ISSN: 1743-7075