Fig. 6

High-fat diet in childhood increases anxiety and decreases memory when they reach young adulthood. a, b Time spent exploring and distance in the open arms of the elevated plus maze was significantly decreased in HF-C as compared with CH-C mice. c, d Time spent and total distance traveled in the inner zone of the open field were no significantly difference in two groups. e, f Time in food arm was no significantly difference but food arm entries of HF-C was lower than CF-C group in y-maze test. g Marble-burying behavior was no significantly difference in two groups. h Novelty-suppressed feeding was significantly difference in two groups. i–l Quantification of the levels of protein to NeuN, BDNF, TH and AVP in hypothalamus by western blotting. Data are means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001