From: Discovery of metabolic biomarkers for gestational diabetes mellitus in a Chinese population
 | Subjects in the second trimester | Subjects in the third trimester | ||||
---|---|---|---|---|---|---|
NGT (n = 200) | GDM (n = 200) | P | NGT (n = 199) | GDM (n = 199) | P | |
Age (years) | 29 (27,30) | 29 (27,30) | 0.117 | 31 (29,34) | 31 (29,35) | 0.208 |
Pregestational BMI (kg/m2) | 20.33 ± 2.58 | 20.72 ± 2.77 | 0.151 | 21.33 ± 2.26 | 21.44 ± 2.39 | 0.665 |
Changes of BMI (kg/m2) | 5.26 ± 1.31 | 4.63 ± 1.47 |  < 0.001 | 5.6 ± 1.46 | 4.68 ± 1.61 |  < 0.001 |
Gestational age (week) | 25.71 (24.86, 26.43) | 25.86 (25, 26.5) | 0.925 | 29 (28, 31.1) | 29.29 (28, 31.1) | 0.395 |
FBG (mmol/L) | 4.4 ± 0.32 | 4.56 ± 0.38 |  < 0.001 | 4.49 ± 0.25 | 4.63 ± 0.33 |  < 0.001 |
1 h-PG (mmol/L) | 7.22 ± 1.29 | 9.67 ± 1.34 |  < 0.001 | 7.35 ± 1.37 | 9.94 ± 1.51 |  < 0.001 |
2 h-PG (mmol/L) | 6.27 ± 0.92 | 8.5 ± 1.35 |  < 0.001 | 6.44 ± 1.06 | 8.79 ± 1.56 |  < 0.001 |
HbA1c |  |  |  < 0.001 |  |  | 0.962 |
mmol/mol | 32.47 ± 2.08 | 33.45 ± 2.53 |  | 32.93 ± 3.52 | 32.94 ± 3.14 |  |
% | 5.12 ± 0.19 | 5.21 ± 0.23 |  | 5.16 ± 0.32 | 5.16 ± 0.29 |  |
Total cholesterol (mmol/L) | 6.13 ± 1.05 | 5.83 ± 1.11 | 0.005 | 6.64 ± 1.22 | 6.13 ± 1.16 |  < 0.001 |
Triglycerides (mmol/L) | 1.93 ± 0.65 | 2.33 ± 0.86 |  < 0.001 | 2.91 ± 1.38 | 2.94 ± 1.78 | 0.850 |
LDL-C (mmol/L) | 2.91 ± 0.74 | 3.24 ± 0.96 |  < 0.001 | 3.29 ± 0.89 | 3.40 ± 0.91 | 0.233 |
HDL-C (mmol/L) | 2.05 ± 0.37 | 2.02 ± 0.42 | 0.488 | 1.98 ± 0.39 | 1.95 ± 0.40 | 0.395 |
Delivery gestational age (week) | 39 (38,40) | 39 (38,40) | 0.120 | 39 (39,40) | 39 (38,40) | 0.004 |
Neonatal weight (kg) | 3.29 ± 0.38 | 3.23 ± 0.46 | 0.127 | 3.38 ± 0.39 | 3.26 ± 0.41 | 0.005 |
Neonatal length (cm) | 50 (50,50) | 50 (50,50) | 0.214 | 50 (50,51) | 50 (50,50) | 0.010 |
Family history of diabetes, n (%) | 5(2.5) | 48(24) |  < 0.001 | 27(13.6) | 53(26.6) | 0.001 |