Table 3 Enrichment analysis of the third trimester group
From: Discovery of metabolic biomarkers for gestational diabetes mellitus in a Chinese population
Pathway associated metabolite sets | Enriched compounds | Total | Hits | Raw p | Holm p | FDR |
|---|---|---|---|---|---|---|
Urea cycle | Pyruvic acid; Oxoglutaric acid; L-Alanine; L-Arginine;L-Glutamine Citrulline | 29 | 6 | 0.000325 | 0.0318 | 0.0176 |
Ammonia recycling | Glycine; L-Histidine; L-Glutamine; L-Serine; Oxoglutaric acid; Pyruvic acid | 32 | 6 | 0.000574 | 0.0557 | 0.0176 |
Glycine and serine metabolism | Glycine;Guanidoacetic acid;Pyruvic acid;L-Alanine;L-Serine;L-Arginine Oxoglutaric acid; L-Methionine | 59 | 8 | 0.000638 | 0.0612 | 0.0176 |
Valine-leucine-isoleucine degradation | Alpha-ketoisovaleric acid; L-Valine; Methylmalonic acid; Oxoglutaric acid; Succinic acid; Ketoleucine; 3-Methyl-2-oxovaleric acid; L- Leucine | 60 | 8 | 0.000718 | 0.0682 | 0.0176 |
Arginine and proline metabolism | Glycine; Guanidoacetic acid; L- Proline; Oxoglutaric acid; Succinic acid; L-Arginine; Citrulline | 53 | 7 | 0.00173 | 0.163 | 0.034 |
Alanine metabolism | Glycine; Oxoglutaric acid; Pyruvic acid; L-Alanine | 17 | 4 | 0.00221 | 0.206 | 0.0362 |
Glutamate metabolism | Glycine; L-Alanine; Oxoglutaric acid; Pyruvic acid; Succinic acid; L-Glutamine | 49 | 6 | 0.00571 | 0.525 | 0.0747 |
Aspartate metabolism | Oxoglutaric acid; L-Arginine; L- Glutamine; N-Acetyl-L-aspartic acid; Citrulline | 35 | 5 | 0.00609 | 0.555 | 0.0747 |
Glucose-alanine cycle | L-Alanine; Oxoglutaric acid; Pyruvic acid | 13 | 3 | 0.00896 | 0.807 | 0.0976 |
Phenylalanine and tyrosine Metabolism | L-Tyrosine; Phenylpyruvic acid; 4-Hydroxyphenylpyruvic acid; Oxoglutaric acid | 28 | 4 | 0.0144 | 1 | 0.141 |
Carnitine synthesis | Glycine; Oxoglutaric acid; Succinic acid | 22 | 3 | 0.0388 | 1 | 0.346 |