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Table 2 Association between HPV and metabolic alterations

From: Metabolic reprogramming in cervical cancer and metabolomics perspectives

HPV viral protein Direct target Secondary target Enzyme Metabolic process
E6 c-MYC   HK2 Glycolysis
miR-143-3p   HK2 Glycolysis
p53 miR-34a LDHA Lactate
   Glycolysis
  SREBP1C Lipogenic
  Lpin1, MCD, CPT1 FAO
miRNA-107, PANK1 FASN, SCD1, CPT1α Lipid metabolism
  SLC7A3 Arginine uptake
  GLS2 Glutamine metabolism
E7 miR-143-3p   HK2 Glycolysis
Rb1   GLUT1, HK2, PKM2 Glycolysis
E2F1 GLUT2, GCK, PDK4, FBP, PKLR Glycolysis
ACACA FASN, CHREBP, SREBP1C, CKB, Lipogenic
PI3K/Akt/mTOR   PFK1, GLUT Glycolysis
  1. Summary of the mechanisms by which HPV regulates metabolism. The responsible HPV viral proteins, their targets, the modified enzymes and corresponding metabolic processes are listed