Metabolic reprogramming in cervical cancer and metabolomics perspectives

Nutrition & Metabolism

Table 2 Association between HPV and metabolic alterations

HPV viral protein	Direct target	Secondary target	Enzyme	Metabolic process
E6	c-MYC		HK2	Glycolysis
	miR-143-3p		HK2	Glycolysis
	p53	miR-34a	LDHA	Lactate
				Glycolysis
			SREBP1C	Lipogenic
			Lpin1, MCD, CPT1	FAO
		miRNA-107, PANK1	FASN, SCD1, CPT1α	Lipid metabolism
			SLC7A3	Arginine uptake
			GLS2	Glutamine metabolism
E7	miR-143-3p		HK2	Glycolysis
	Rb1		GLUT1, HK2, PKM2	Glycolysis
		E2F1	GLUT2, GCK, PDK4, FBP, PKLR	Glycolysis
		E2F1	ACACA FASN, CHREBP, SREBP1C, CKB,	Lipogenic
	PI3K/Akt/mTOR		PFK1, GLUT	Glycolysis

Summary of the mechanisms by which HPV regulates metabolism. The responsible HPV viral proteins, their targets, the modified enzymes and corresponding metabolic processes are listed

ISSN: 1743-7075