Metabolic reprogramming in cervical cancer and metabolomics perspectives

Nutrition & Metabolism

Table 3 Metabolites, enzymes and transporters involved in cervical cancer and their related phenotypes

Metabolic pathway	Specific factors involved		Related phenotypes
Glycometabolism	Metabolites	Lactate	Pro-cancerous M2 macrophage, DNA repair after chemotherapy
	Enzymes	LDHA	Proliferation, invasion
	Enzymes	PKM2	Radioresistant
Lipid metabolism	Metabolites	Membrane compositions	Migration
	Metabolites	Oleic acid	Proliferation, invasion
	Transporters	CD36	Proliferation, invasion
Amino acid metabolism	Metabolites	Kynurenine	Immunologic tolerance, metastasis

Several specific metabolites, enzymes and transporters have been confirmed in experimental studies to be related to cancerous phenotypes in cervical cancer. Metabolic alterations are relevant to various malignant biological properties of cancer, including increased proliferation, distant metastasis and immune escape

ISSN: 1743-7075