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Table 2 Association between SUA levels and incident CKD in China

From: Serum uric acid and risk of incident chronic kidney disease: a national cohort study and updated meta-analysis

 

CKD* / no. of participants

Model 1

OR (95% CI)

Model 2

OR (95% CI)

Model 3

OR (95% CI)

Hyperuricemia#

    

 No

156/4208

1.00 (reference)

1.00 (reference)

1.00 (reference)

 Yes

23/338

1.87 (1.07–3.27)

1.82 (1.04–3.20)

1.73 (0.98–3.06)

SUA levels

    

 Quartile 1

27/1165

1.00

1.00

1.00

 Quartile 2

38/1133

1.46 (0.88–2.41)

1.44 (0.87–2.39)

1.44 (0.86–2.38)

 Quartile 3

49/1150

1.93 (1.18–3.15)

1.89 (1.16–3.10)

1.89 (1.15–3.10)

 Quartile 4

66/1098

2.80 (1.72–4.56)

2.77 (1.69–4.55)

2.73 (1.65–4.50)

 P for trend

 

P < 0.001

P < 0.001

P < 0.001

Each 1 mg/dL

 

1.49 (1.29–1.73)

1.50 (1.29–1.74)

1.49 (1.28–1.74)

  1. Model 1: adjusted for age (continuous, years), sex (male and female), residence area (rural and urban), education level (illiterate, primary school, middle school or above). Model 2: adjusted for variables in Model 1 plus body mass index (continuous, kg/m2), smoking status (never, former, and current), and alcohol consumption (never, former, and current); Model 3: adjusted for variables in Model 2 plus systolic BP (continuous, mmHg), total cholesterol (continuous, mg/dL), triglyceride (continuous, mg/dL), and prevalent diabetes mellitus (yes and no)
  2. CKD, chronic kidney disease; CI, confidence interval; OR, odds ratio; SUA, serum uric acid
  3. *CKD which was defined as eGFR < 60 mL/min/1.73 m2 based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
  4. # Hyperuricemia was defined as a level of SUA ≥ 7.0 mg/dL in men or ≥ 6.0 mg/dL in women
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Nutrition & Metabolism

ISSN: 1743-7075

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