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Table 2 Association between SUA levels and incident CKD in China

From: Serum uric acid and risk of incident chronic kidney disease: a national cohort study and updated meta-analysis

  CKD* / no. of participants Model 1
OR (95% CI)
Model 2
OR (95% CI)
Model 3
OR (95% CI)
Hyperuricemia#     
 No 156/4208 1.00 (reference) 1.00 (reference) 1.00 (reference)
 Yes 23/338 1.87 (1.07–3.27) 1.82 (1.04–3.20) 1.73 (0.98–3.06)
SUA levels     
 Quartile 1 27/1165 1.00 1.00 1.00
 Quartile 2 38/1133 1.46 (0.88–2.41) 1.44 (0.87–2.39) 1.44 (0.86–2.38)
 Quartile 3 49/1150 1.93 (1.18–3.15) 1.89 (1.16–3.10) 1.89 (1.15–3.10)
 Quartile 4 66/1098 2.80 (1.72–4.56) 2.77 (1.69–4.55) 2.73 (1.65–4.50)
 P for trend   P < 0.001 P < 0.001 P < 0.001
Each 1 mg/dL   1.49 (1.29–1.73) 1.50 (1.29–1.74) 1.49 (1.28–1.74)
  1. Model 1: adjusted for age (continuous, years), sex (male and female), residence area (rural and urban), education level (illiterate, primary school, middle school or above). Model 2: adjusted for variables in Model 1 plus body mass index (continuous, kg/m2), smoking status (never, former, and current), and alcohol consumption (never, former, and current); Model 3: adjusted for variables in Model 2 plus systolic BP (continuous, mmHg), total cholesterol (continuous, mg/dL), triglyceride (continuous, mg/dL), and prevalent diabetes mellitus (yes and no)
  2. CKD, chronic kidney disease; CI, confidence interval; OR, odds ratio; SUA, serum uric acid
  3. *CKD which was defined as eGFR < 60 mL/min/1.73 m2 based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
  4. # Hyperuricemia was defined as a level of SUA ≥ 7.0 mg/dL in men or ≥ 6.0 mg/dL in women