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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: PA and OA induce abnormal glucose metabolism by inhibiting KLF15 in adipocytes

Fig. 6

OA inhibits KLF15 expression mainly through GPR120 while not dependent on P-p38 MAPK, resulting in abnormal glucose metabolism of 3T3-L1 adipocytes. 3T3-L1 adipocytes were treated with different concentration OA (0, 15, 150, and 750 μM) for 48 h. The mRNA (A) and protein B expression levels of GPR120, GPR40, P-p38 MAPK, and KLF15 were detected; Glucose consumption C of 3T3-L1 adipocytes was tested. AH7614 and GW1100 were respectively added into 1500 μM PA treated cells to block GPR120 and GPR40. The mRNA (D) and protein EG levels of P-p38 MAPK, KLF15 and glucose consumption H were detected. Pattern diagram I were presented. Results represent mean ± SEM. One-way ANOVA, *P < 0.05, **P < 0.01 versus the control group, #P < 0.05, ###P < 0.001 versus the OA-treated group, difference was statistically significant

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