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Table 4 B vitamin biomarkers before and after intervention with a B vitamin-fortified and placebo drink

From: Effectiveness of a fortified drink in improving B vitamin biomarkers in older adults: a controlled intervention trial

  Placebo Active P value
Pre-intervention Post-intervention Pre-intervention Post-intervention
Plasma Total 25(OH)D (nmol/L) 62.5 (22.4) 66.9 (17.0) 59.3 (25.20) 65.5 (25.8) 0.727
Serum homocysteine (µmol/L) 11.1 (9.7–12.8) 11.3 (9.9–13.2) 11.9 (10.3–15.1) 10.6 (9.4–13.0) 0.000240
Serum folate (nmol/L) 18.0 (14.3–22.0) 16.6 (13.0–21.8) 15.5 (11.8–21.6) 17.9 (12.7–23.6) 0.000439
Serum vitamin B12 (pmol/L) 336 (235–449) 342 (268–468) 310 (246–409) 428 (307–549) 0.005
Plasma PLP (vitamin B6; (nmol/L) 61.7 (48.6–85.1) 65.4 (38.3–104.9) 59.4 (44.5–74.1) 253.0 (181.0–351.4) 0.002
Riboflavin (EGRac) 1.29 (1.24–1.35) 1.30 (1.23–1.36) 1.34 (1.25–1.43) 1.14 (1.09–1.23) 3.2014 × 10–9
  1. Data presented as mean (SD) or median (IQR). P value of group effects when analysed by ANCOVA adjusted for baseline values in intention-to-treat analysis. P < 0.05 considered statistically significant. EGRac, erythrocyte glutathione reductase activation coefficient; PLP, Pyridoxal 5′-phosphate